Reaction Details Report a problem with these data
Target
Monoacylglycerol lipase ABHD2
Ligand
BDBM280618
Substrate
n/a
Meas. Tech.
In Vitro Competitive Activity-Based Protein Profiling
IC50
550±n/a nM
Citation
 Cisar, JS; Grice, CA; Jones, TK; Weber, OD; Buzard, DJ; Shaghafi, MB Spirocycle compounds and methods of making and using same US Patent  US10030020 Publication Date 7/24/2018 
Target
Name:
Monoacylglycerol lipase ABHD2
Synonyms:
2-arachidonoylglycerol hydrolase | ABHD2_MOUSE | Abhd2 | Abhydrolase domain-containing protein 2 | Labh-2 | Labh2 | Lung alpha/beta hydrolase 2 | MmLABH2
Type:
Enzyme Catalytic Domain
Mol. Mass.:
48378.90
Organism:
Mus musculus (Mouse)
Description:
n/a
Residue:
425
Sequence:
MNAMLETPELPAVFDGVKLAAVAAVLYVIVRCLNLKSPTAPPDLYFQDSGLSRFLLKSCPLLTKEYIPPLIWGKSGHIQTALYGKMGRVRSPHPYGHRKFITMSDGATSTFDLFEPLAEHCVGDDITMVICPGIANHSEKQYIRTFVDYAQKNGYRCAVLNHLGALPNIELTSPRMFTYGCTWEFGAMVNYIKRTYPQTQLVVVGFSLGGNIVCKYLGETQANQEKVLCCVSVCQGYSALRAQETFMQWDQCRRFYNFLMADNMKKIILSHRQALFGDHVKKPQSLEDTDLSRLYTATSLMQIDDNVMRKFHGYNSLKEYYEEESCMRYLHRIYVPLMLVNAADDPLVHESLLTIPKSLSEKRENVMFVLPLHGGHLGFFEGSVLFPEPLTWMDKLVVEYANAICQWERNKSQCSDTEQMEAELE
  
Inhibitor
Name:
BDBM280618
Synonyms:
US10030020, Example 163 | US10781211, Example 163
Type:
Small organic molecule
Emp. Form.:
C25H31F6N3O2
Mol. Mass.:
519.523
SMILES:
FC(F)(F)C(OC(=O)N1CCC2(CCN(Cc3cccc4CCN(Cc34)C3CC3)C2)CC1)C(F)(F)F
Structure:
Search PDB for entries with ligand similarity: