Target
Guanylate cyclase soluble subunit alpha-1
Ligand
BDBM280813
Substrate
n/a
Meas. Tech.
sGC Binding Assay
pH
7.4±n/a
Ki
0.063±n/a nM
Comments
extracted
Citation
 Berger, RChen, YLi, GGarfunkle, JLi, HMiao, SRaghavan, SSmith, CJStelmach, JWhitehead, AZhang, RZhang, YFu, JJi, GJiang, F Soluble guanylate cyclase stimulators US Patent  US10030027 Publication Date 7/24/2018 
Target
Name:
Guanylate cyclase soluble subunit alpha-1
Synonyms:
GCS-alpha-1 | GCS-alpha-3 | GCYA1_HUMAN | GUC1A3 | GUCSA3 | GUCY1A1 | GUCY1A3 | Guanylate cyclase soluble (GCS-alpha-1) | Guanylate cyclase soluble subunit alpha-3 | Solube guanylate cyclase alpha-1 (sGC alpha-1) | Solube guanylate cyclase alpha-1 (sGCalpha) | soluble guanylate cyclase alpha-1 (sGC)
Type:
Enzyme
Mol. Mass.:
77457.21
Organism:
Homo sapiens (Human)
Description:
Q02108
Residue:
690
Sequence:
MFCTKLKDLKITGECPFSLLAPGQVPNESSEEAAGSSESCKATVPICQDIPEKNIQESLPQRKTSRSRVYLHTLAESICKLIFPEFERLNVALQRTLAKHKIKESRKSLEREDFEKTIAEQAVAAGVPVEVIKESLGEEVFKICYEEDENILGVVGGTLKDFLNSFSTLLKQSSHCQEAGKRGRLEDASILCLDKEDDFLHVYYFFPKRTTSLILPGIIKAAAHVLYETEVEVSLMPPCFHNDCSEFVNQPYLLYSVHMKSTKPSLSPSKPQSSLVIPTSLFCKTFPFHFMFDKDMTILQFGNGIRRLMNRRDFQGKPNFEEYFEILTPKINQTFSGIMTMLNMQFVVRVRRWDNSVKKSSRVMDLKGQMIYIVESSAILFLGSPCVDRLEDFTGRGLYLSDIPIHNALRDVVLIGEQARAQDGLKKRLGKLKATLEQAHQALEEEKKKTVDLLCSIFPCEVAQQLWQGQVVQAKKFSNVTMLFSDIVGFTAICSQCSPLQVITMLNALYTRFDQQCGELDVYKVETIGDAYCVAGGLHKESDTHAVQIALMALKMMELSDEVMSPHGEPIKMRIGLHSGSVFAGVVGVKMPRYCLFGNNVTLANKFESCSVPRKINVSPTTYRLLKDCPGFVFTPRSREELPPNFPSEIPGICHFLDAYQQGTNSKPCFQKKDVEDGNANFLGKASGID
  
Inhibitor
Name:
BDBM280813
Synonyms:
(S)-3-(2-{4-amino-2-[1- (2-fluorobenzyl)-1H- pyrazolo[3,4-b]pyridin- 3-yl]-5-methyl-6-oxo- 6,7-dihydro-5H- pyrrolo[2,3- d]pyrimidin-5-yl}-1,3- thiazol-4-yl)-2,2- dimethylpropanoic acid | US10030027, Example 90B | US10428076, Example 90B
Type:
Small organic molecule
Emp. Form.:
C28H25FN8O3S
Mol. Mass.:
572.613
SMILES:
CC(C)(Cc1csc(n1)[C@]1(C)C(=O)Nc2nc(nc(N)c12)-c1nn(Cc2ccccc2F)c2ncccc12)C(O)=O |r|
Structure:
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