Reaction Details Report a problem with these data
Target
3-phosphoinositide-dependent protein kinase 1
Ligand
BDBM50296949
Substrate
n/a
Meas. Tech.
AlphaScreen Assay
pH
7.4±n/a
Temperature
273.15±n/a K
IC50
9.7e+4±n/a nM
Citation
 Pastor-Flores, D; Schulze, JO; Bahí, A; Bahí, R; Ferrer-Dalmau, J; Passeron, S; Engel, M; Süss, E; Süss, A; Biondi, RM PIF-pocket as a target for C. albicans Pkh selective inhibitors. ACS Chem Biol 8:2283-92 (2013) [PubMed]  Article 
Target
Name:
3-phosphoinositide-dependent protein kinase 1
Synonyms:
3-Phosphoinositide-Dependent Protein Kinase 1 (PDK1) | 3-phosphoinositide dependent protein kinase-1 | 3-phosphoinositide-dependent protein kinase 1 | 3-phosphoinositide-dependent protein kinase 1 (PDK) | 3-phosphoinositide-dependent protein kinase 1 (PDK-1) | 3-phosphoinositide-dependent protein kinase 1 (PDK1)(Δ1-50) | Isoform 2 of 3-phosphoinositide-dependent protein kinase 1 | PDK1 | PDPK1 | PDPK1_HUMAN | Phosphoinositide-dependent protein kinase 1 (PDK1) | Pyruvate dehydrogenase kinase isoenzyme 1 (PDK1) | hPDK1
Type:
Enzyme
Mol. Mass.:
63157.65
Organism:
Homo sapiens (Human)
Description:
O15530
Residue:
556
Sequence:
MARTTSQLYDAVPIQSSVVLCSCPSPSMVRTQTESSTPPGIPGGSRQGPAMDGTAAEPRPGAGSLQHAQPPPQPRKKRPEDFKFGKILGEGSFSTVVLARELATSREYAIKILEKRHIIKENKVPYVTRERDVMSRLDHPFFVKLYFTFQDDEKLYFGLSYAKNGELLKYIRKIGSFDETCTRFYTAEIVSALEYLHGKGIIHRDLKPENILLNEDMHIQITDFGTAKVLSPESKQARANSFVGTAQYVSPELLTEKSACKSSDLWALGCIIYQLVAGLPPFRAGNEYLIFQKIIKLEYDFPEKFFPKARDLVEKLLVLDATKRLGCEEMEGYGPLKAHPFFESVTWENLHQQTPPKLTAYLPAMSEDDEDCYGNYDNLLSQFGCMQVSSSSSSHSLSASDTGLPQRSGSNIEQYIHDLDSNSFELDLQFSEDEKRLLLEKQAGGNPWHQFVENNLILKMGPVDKRKGLFARRRQLLLTEGPHLYYVDPVNKVLKGEIPWSQELRPEAKNFKTFFVHTPNRTYYLMDPSGNAHKWCRKIQEVWRQRYQSHPDAAVQ
  
Inhibitor
Name:
BDBM50296949
Synonyms:
(2Z)-5-(4-chlorophenyl)-3-phenylpent-2-enoic acid | (Z)-5-(4-Chlorophenyl)-3-phenylpent-2-enoicAcid | (Z)-5-(4-chlorophenyl)-3-phenylpent-2-enoic acid | CHEMBL539134 | PS48
Type:
Small organic molecule
Emp. Form.:
C17H15ClO2
Mol. Mass.:
286.753
SMILES:
OC(=O)\C=C(\CCc1ccc(Cl)cc1)c1ccccc1
Structure:
Search PDB for entries with ligand similarity: