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Target
Serine/threonine-protein kinase pim-1
Ligand
BDBM41535
Substrate
n/a
Meas. Tech.
PIM-1 Enzyme Assay
pH
7.4±0
Temperature
295.15±0 K
IC50
0.8±0.0 nM
Citation
 Allen, S; Celeste, LL; Davis, TG; DeLisle, RK; Greschuk, JM; Gross, SD; Hicken, EJ; Jackson, LJ; Kallan, NC; Lyssikatos, JP; Marmsater, FP; Munson, MC; Pheneger, J; Rast, B; Robinson, JE; Schlachter, ST; Topalov, GT; Wright, AD; Zhao, Q Triazolopyridine compounds as PIM kinase inhibitors US Patent  US8575145 Publication Date 11/5/2013 
Target
Name:
Serine/threonine-protein kinase pim-1
Synonyms:
PIM-1 Kinase | PIM1 | PIM1_HUMAN | Proto-oncogene serine/threonine-protein kinase Pim-1 | Serine/threonine-protein kinase (PIM1) | Serine/threonine-protein kinase PIM | Serine/threonine-protein kinase PIM1 | Serine/threonine-protein kinase pim-1 (PIM1)
Type:
Protein
Mol. Mass.:
35681.82
Organism:
Homo sapiens (Human)
Description:
P11309
Residue:
313
Sequence:
MLLSKINSLAHLRAAPCNDLHATKLAPGKEKEPLESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYTDFDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEEIIRGQVFFRQRVSSECQHLIRWCLALRPSDRPTFEEIQNHPWMQDVLLPQETAEIHLHSLSPGPSK
  
Inhibitor
Name:
BDBM41535
Synonyms:
US8575145, 106 | US8575145, 66
Type:
n/a
Emp. Form.:
C21H20FN5O
Mol. Mass.:
377.4148
SMILES:
FC1(COc2cccc3ccc(nc23)-c2nnc3ccccn23)CCNCC1
Structure:
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