Target
Serine/threonine-protein kinase pim-1
Ligand
BDBM104213
Substrate
n/a
Meas. Tech.
PIM-1 Enzyme Assay
pH
7.4±0
Temperature
295.15±0 K
IC50
11±0.0 nM
Citation
 Allen, SCeleste, LLDavis, TGDeLisle, RKGreschuk, JMGross, SDHicken, EJJackson, LJKallan, NCLyssikatos, JPMarmsater, FPMunson, MCPheneger, JRast, BRobinson, JESchlachter, STTopalov, GTWright, ADZhao, Q Triazolopyridine compounds as PIM kinase inhibitors US Patent  US8575145 Publication Date 11/5/2013 
Target
Name:
Serine/threonine-protein kinase pim-1
Synonyms:
PIM-1 Kinase | PIM1 | PIM1_HUMAN | Proto-oncogene serine/threonine-protein kinase Pim-1 | Serine/threonine-protein kinase (PIM1) | Serine/threonine-protein kinase PIM | Serine/threonine-protein kinase PIM1 | Serine/threonine-protein kinase pim-1 (PIM1)
Type:
Protein
Mol. Mass.:
35681.82
Organism:
Homo sapiens (Human)
Description:
P11309
Residue:
313
Sequence:
MLLSKINSLAHLRAAPCNDLHATKLAPGKEKEPLESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYTDFDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEEIIRGQVFFRQRVSSECQHLIRWCLALRPSDRPTFEEIQNHPWMQDVLLPQETAEIHLHSLSPGPSK
  
Inhibitor
Name:
BDBM104213
Synonyms:
US8575145, 120 | US8575145, 121 | US8575145, 150 | US8575145, 151 | US8575145, 90 | US8575145, 91
Type:
Small organic molecule
Emp. Form.:
C21H19F2N5O
Mol. Mass.:
395.4053
SMILES:
FC1CCNCCC1Oc1cc(F)cc2ccc(nc12)-c1nnc2ccccn12
Structure:
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