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TargetSerine/threonine-protein kinase pim-2
LigandBDBM104222
Substrate/Competitorn/a
Meas. Tech.PIM-2 Enzyme Assay
pH7.4±0
Temperature295.15±0 K
IC50 1000±0.0 nM
Citation Allen, SCeleste, LLDavis, TGDeLisle, RKGreschuk, JMGross, SDHicken, EJJackson, LJKallan, NCLyssikatos, JPMarmsater, FPMunson, MCPheneger, JRast, BRobinson, JESchlachter, STTopalov, GTWright, ADZhao, Q Triazolopyridine compounds as PIM kinase inhibitors US Patent US8575145 Publication Date 11/5/2013
More Info.:Get all data from this article,   Solution Info,  Assay Method
 
Serine/threonine-protein kinase pim-2
Name:Serine/threonine-protein kinase PIM
Synonyms:Pim-2h | Serine/threonine-protein kinase (PIM2) | Serine/threonine-protein kinase pim-2 (PIM2)
Type:Serine/threonine-protein kinase
Mol. Mass.:34185.93
Organism:Homo sapiens (Human)
Description:Q9P1W9
Residue:311
Sequence:
MLTKPLQGPPAPPGTPTPPPGGKDREAFEAEYRLGPLLGKGGFGTVFAGHRLTDRLQVAI
KVIPRNRVLGWSPLSDSVTCPLEVALLWKVGAGGGHPGVIRLLDWFETQEGFMLVLERPL
PAQDLFDYITEKGPLGEGPSRCFFGQVVAAIQHCHSRGVVHRDIKDENILIDLRRGCAKL
IDFGSGALLHDEPYTDFDGTRVYSPPEWISRHQYHALPATVWSLGILLYDMVCGDIPFER
DQEILEAELHFPAHVSPDCCALIRRCLAPKPSSRPSLEEILLDPWMQTPAEDVPLNPSKG
GPAPLAWSLLP
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM104222
NameBDBM104222
Synonyms:US8575145, 130 | US8575145, 99/100
TypeSmall organic molecule
Emp. Form.C22H22FN5O
Mol. Mass.391.4414
SMILESCc1ccc2nnc(-c3ccc4cccc(OC5CCNCCC5F)c4n3)n2c1
Structure
n/a