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TargetSerine/threonine-protein kinase pim-2
LigandBDBM104228
Substrate/Competitorn/a
Meas. Tech.PIM-2 Enzyme Assay
pH7.4±0
Temperature295.15±0 K
IC50 409±0.0 nM
Citation Allen, S; Celeste, LL; Davis, TG; DeLisle, RK; Greschuk, JM; Gross, SD; Hicken, EJ; Jackson, LJ; Kallan, NC; Lyssikatos, JP; Marmsater, FP; Munson, MC; Pheneger, J; Rast, B; Robinson, JE; Schlachter, ST; Topalov, GT; Wright, AD; Zhao, Q Triazolopyridine compounds as PIM kinase inhibitors US Patent US8575145 Publication Date 11/5/2013
More Info.:Get all data from this article,   Solution Info,  Assay Method
 
Serine/threonine-protein kinase pim-2
Name:Serine/threonine-protein kinase PIM
Synonyms:Pim-2h | Serine/threonine-protein kinase (PIM2) | Serine/threonine-protein kinase pim-2 (PIM2)
Type:Serine/threonine-protein kinase
Mol. Mass.:34185.93
Organism:Homo sapiens (Human)
Description:Q9P1W9
Residue:311
Sequence:
MLTKPLQGPPAPPGTPTPPPGGKDREAFEAEYRLGPLLGKGGFGTVFAGHRLTDRLQVAI
KVIPRNRVLGWSPLSDSVTCPLEVALLWKVGAGGGHPGVIRLLDWFETQEGFMLVLERPL
PAQDLFDYITEKGPLGEGPSRCFFGQVVAAIQHCHSRGVVHRDIKDENILIDLRRGCAKL
IDFGSGALLHDEPYTDFDGTRVYSPPEWISRHQYHALPATVWSLGILLYDMVCGDIPFER
DQEILEAELHFPAHVSPDCCALIRRCLAPKPSSRPSLEEILLDPWMQTPAEDVPLNPSKG
GPAPLAWSLLP
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  Blast E-value cutoff:
BDBM104228
NameBDBM104228
Synonyms:US8575145, 105
TypeSmall organic molecule
Emp. Form.C23H23F2N5O
Mol. Mass.423.4584
SMILESFCCN1CCC(F)(COc2cccc3ccc(nc23)-c2nnc3ccccn23)CC1
Structure
n/a