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Target
Serine/threonine-protein kinase pim-3
Ligand
BDBM104222
Substrate
n/a
Meas. Tech.
PIM-3 Enzyme Assay
pH
7.4±0
Temperature
295.15±0 K
IC50
2±0.0 nM
Citation
 Allen, S; Celeste, LL; Davis, TG; DeLisle, RK; Greschuk, JM; Gross, SD; Hicken, EJ; Jackson, LJ; Kallan, NC; Lyssikatos, JP; Marmsater, FP; Munson, MC; Pheneger, J; Rast, B; Robinson, JE; Schlachter, ST; Topalov, GT; Wright, AD; Zhao, Q Triazolopyridine compounds as PIM kinase inhibitors US Patent  US8575145 Publication Date 11/5/2013 
Target
Name:
Serine/threonine-protein kinase pim-3
Synonyms:
Kid1 | PIM3_RAT | Pim3
Type:
Protein
Mol. Mass.:
35997.25
Organism:
Rattus norvegicus (Rat)
Description:
O70444
Residue:
326
Sequence:
MLLSKFGSLAHLCGPGGVDHLPVKILQPAKADKESFEKVYQVGAVLGSGGFGTVYAGSRIADGLPVAVKHVVKERVTEWGSLGGMAVPLEVVLLRKVGAAGGARGVIRLLDWFERPDGFLLVLERPEPAQDLFDFITERGALDEPLARRFFAQVLAAVRHCHNCGVVHRDIKDENLLVDLRSGELKLIDFGSGAVLKDTVYTDFDGTRVYSPPEWIRYHRYHGRSATVWSLGVLLYDMVCGDIPFEQDEEILRGRLFFRRRVSPECQQLIEWCLSLRPSERPSLDQIAAHPWMLGTEGSVPENCDLRLCALDTDDGASTTSSSESL
  
Inhibitor
Name:
BDBM104222
Synonyms:
US8575145, 130 | US8575145, 99/100
Type:
Small organic molecule
Emp. Form.:
C22H22FN5O
Mol. Mass.:
391.4414
SMILES:
Cc1ccc2nnc(-c3ccc4cccc(OC5CCNCCC5F)c4n3)n2c1
Structure:
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