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Target
Methyl-CpG-binding domain protein 2
Ligand
BDBM83394
Substrate
n/a
Meas. Tech.
TRFRET-based biochemical high throughput dose response assay to identify inhibitors of 5-meCpG-binding domain protein 2 (MBD2)-DBD binding to methylated oligonucleotide
IC50
8021±n/a nM
Citation
 PubChem, PC TRFRET-based biochemical high throughput dose response assay to identify inhibitors of 5-meCpG-binding domain protein 2 (MBD2)-DBD binding to methylated oligonucleotide PubChem Bioassay (2013)[AID] 
Target
Name:
Methyl-CpG-binding domain protein 2
Synonyms:
MBD2 | MBD2_HUMAN | Methyl-CpG binding domain protein 2 | Methyl-CpG-binding domain protein 2 (MBD2)
Type:
Enzyme Catalytic Domain
Mol. Mass.:
43278.74
Organism:
Homo sapiens (Human)
Description:
gi_21595776
Residue:
411
Sequence:
MRAHPGGGRCCPEQEEGESAAGGSGAGGDSAIEQGGQGSALAPSPVSGVRREGARGGGRGRGRWKQAGRGGGVCGRGRGRGRGRGRGRGRGRGRGRPPSGGSGLGGDGGGCGGGGSGGGGAPRREPVPFPSGSAGPGPRGPRATESGKRMDCPALPPGWKKEEVIRKSGLSAGKSDVYYFSPSGKKFRSKPQLARYLGNTVDLSSFDFRTGKMMPSKLQKNKQRLRNDPLNQNKGKPDLNTTLPIRQTASIFKQPVTKVTNHPSNKVKSDPQRMNEQPRQLFWEKRLQGLSASDVTEQIIKTMELPKGLQGVGPGSNDETLLSAVASALHTSSAPITGQVSAAVEKNPAVWLNTSQPLCKAFIVTDEDIRKQEERVQQVRKKLEEALMADILSRAADTEEMDIEMDSGDEA
  
Inhibitor
Name:
BDBM83394
Synonyms:
3-benzyl-4-chloro-7-methyl-1H-1,8-naphthyridine-2-thione | 3-benzyl-4-chloro-7-methyl[1,8]naphthyridine-2(1H)-thione | 4-chloranyl-7-methyl-3-(phenylmethyl)-1H-1,8-naphthyridine-2-thione | 4-chloro-7-methyl-3-(phenylmethyl)-1H-1,8-naphthyridine-2-thione | MLS001182542 | SMR000477545 | cid_5455972
Type:
Small organic molecule
Emp. Form.:
C16H13ClN2S
Mol. Mass.:
300.806
SMILES:
Cc1ccc2c(Cl)c(Cc3ccccc3)c(=S)[nH]c2n1
Structure:
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