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Target
Methyl-CpG-binding domain protein 2
Ligand
BDBM114639
Substrate
n/a
Meas. Tech.
TRFRET-based biochemical high throughput dose response assay to identify inhibitors of 5-meCpG-binding domain protein 2 (MBD2)-DBD binding to methylated oligonucleotide
IC50
31772±n/a nM
Citation
 PubChem, PC TRFRET-based biochemical high throughput dose response assay to identify inhibitors of 5-meCpG-binding domain protein 2 (MBD2)-DBD binding to methylated oligonucleotide PubChem Bioassay (2013)[AID] 
Target
Name:
Methyl-CpG-binding domain protein 2
Synonyms:
MBD2 | MBD2_HUMAN | Methyl-CpG binding domain protein 2 | Methyl-CpG-binding domain protein 2 (MBD2)
Type:
Enzyme Catalytic Domain
Mol. Mass.:
43278.74
Organism:
Homo sapiens (Human)
Description:
gi_21595776
Residue:
411
Sequence:
MRAHPGGGRCCPEQEEGESAAGGSGAGGDSAIEQGGQGSALAPSPVSGVRREGARGGGRGRGRWKQAGRGGGVCGRGRGRGRGRGRGRGRGRGRGRPPSGGSGLGGDGGGCGGGGSGGGGAPRREPVPFPSGSAGPGPRGPRATESGKRMDCPALPPGWKKEEVIRKSGLSAGKSDVYYFSPSGKKFRSKPQLARYLGNTVDLSSFDFRTGKMMPSKLQKNKQRLRNDPLNQNKGKPDLNTTLPIRQTASIFKQPVTKVTNHPSNKVKSDPQRMNEQPRQLFWEKRLQGLSASDVTEQIIKTMELPKGLQGVGPGSNDETLLSAVASALHTSSAPITGQVSAAVEKNPAVWLNTSQPLCKAFIVTDEDIRKQEERVQQVRKKLEEALMADILSRAADTEEMDIEMDSGDEA
  
Inhibitor
Name:
BDBM114639
Synonyms:
6,8-Dimethyl-4-(3-morpholin-4-yl-propylamino)-quinoline-3-carboxylic acid ethyl ester | 6,8-dimethyl-4-(3-morpholinopropylamino)quinoline-3-carboxylic acid ethyl ester | 6,8-dimethyl-4-[3-(4-morpholinyl)propylamino]-3-quinolinecarboxylic acid ethyl ester | MLS001213001 | SMR000518522 | cid_1566086 | ethyl 6,8-dimethyl-4-(3-morpholin-4-ylpropylamino)quinoline-3-carboxylate
Type:
Small organic molecule
Emp. Form.:
C21H29N3O3
Mol. Mass.:
371.4733
SMILES:
CCOC(=O)c1cnc2c(C)cc(C)cc2c1NCCCN1CCOCC1
Structure:
Search PDB for entries with ligand similarity: