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Target
Methyl-CpG-binding domain protein 2
Ligand
BDBM114641
Substrate
n/a
Meas. Tech.
TRFRET-based biochemical high throughput dose response assay to identify inhibitors of 5-meCpG-binding domain protein 2 (MBD2)-DBD binding to methylated oligonucleotide
IC50
30494±n/a nM
Citation
 PubChem, PC TRFRET-based biochemical high throughput dose response assay to identify inhibitors of 5-meCpG-binding domain protein 2 (MBD2)-DBD binding to methylated oligonucleotide PubChem Bioassay (2013)[AID] 
Target
Name:
Methyl-CpG-binding domain protein 2
Synonyms:
MBD2 | MBD2_HUMAN | Methyl-CpG binding domain protein 2 | Methyl-CpG-binding domain protein 2 (MBD2)
Type:
Enzyme Catalytic Domain
Mol. Mass.:
43278.74
Organism:
Homo sapiens (Human)
Description:
gi_21595776
Residue:
411
Sequence:
MRAHPGGGRCCPEQEEGESAAGGSGAGGDSAIEQGGQGSALAPSPVSGVRREGARGGGRGRGRWKQAGRGGGVCGRGRGRGRGRGRGRGRGRGRGRPPSGGSGLGGDGGGCGGGGSGGGGAPRREPVPFPSGSAGPGPRGPRATESGKRMDCPALPPGWKKEEVIRKSGLSAGKSDVYYFSPSGKKFRSKPQLARYLGNTVDLSSFDFRTGKMMPSKLQKNKQRLRNDPLNQNKGKPDLNTTLPIRQTASIFKQPVTKVTNHPSNKVKSDPQRMNEQPRQLFWEKRLQGLSASDVTEQIIKTMELPKGLQGVGPGSNDETLLSAVASALHTSSAPITGQVSAAVEKNPAVWLNTSQPLCKAFIVTDEDIRKQEERVQQVRKKLEEALMADILSRAADTEEMDIEMDSGDEA
  
Inhibitor
Name:
BDBM114641
Synonyms:
MLS001097547 | N-(6-amino-1-butyl-2,4-diketo-pyrimidin-5-yl)-N-butyl-3-pyrrol-1-yl-benzamide | N-(6-amino-1-butyl-2,4-dioxo-5-pyrimidinyl)-N-butyl-3-(1-pyrrolyl)benzamide | N-(6-amino-1-butyl-2,4-dioxopyrimidin-5-yl)-N-butyl-3-pyrrol-1-ylbenzamide | N-[6-azanyl-1-butyl-2,4-bis(oxidanylidene)pyrimidin-5-yl]-N-butyl-3-pyrrol-1-yl-benzamide | SMR000709771 | cid_24979630
Type:
Small organic molecule
Emp. Form.:
C23H29N5O3
Mol. Mass.:
423.5081
SMILES:
CCCCN(C(=O)c1cccc(c1)-n1cccc1)c1c(N)n(CCCC)c(=O)[nH]c1=O
Structure:
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