Reaction Details Report a problem with these data
Target
UDP-N-acetylglucosamine 1-carboxyvinyltransferase
Ligand
BDBM119068
Substrate
n/a
IC50
6e+3±n/a nM
Citation
 Hrast, M; Sosic, I; Sink, R; Gobec, S Inhibitors of the peptidoglycan biosynthesis enzymes MurA-F. Bioorg Chem 55:2-15 (2014) [PubMed]  Article 
Target
Name:
UDP-N-acetylglucosamine 1-carboxyvinyltransferase
Synonyms:
EPT | Enoylpyruvate transferase | MURA_ECOLI | MurA (E. coli) | UDP-N-acetylglucosamine 1-carboxyvinyltransferase | UDP-N-acetylglucosamine enolpyruvyl transferase | murA | murZ
Type:
Protein
Mol. Mass.:
44814.62
Organism:
Escherichia coli K-12 (Enterobacteria)
Description:
E. coli MurA
Residue:
419
Sequence:
MDKFRVQGPTKLQGEVTISGAKNAALPILFAALLAEEPVEIQNVPKLKDVDTSMKLLSQLGAKVERNGSVHIDARDVNVFCAPYDLVKTMRASIWALGPLVARFGQGQVSLPGGCTIGARPVDLHISGLEQLGATIKLEEGYVKASVDGRLKGAHIVMDKVSVGATVTIMCAATLAEGTTIIENAAREPEIVDTANFLITLGAKISGQGTDRIVIEGVERLGGGVYRVLPDRIETGTFLVAAAISRGKIICRNAQPDTLDAVLAKLRDAGADIEVGEDWISLDMHGKRPKAVNVRTAPHPAFPTDMQAQFTLLNLVAEGTGFITETVFENRFMHVPELSRMGAHAEIESNTVICHGVEKLSGAQVMATDLRASASLVLAGCIAEGTTVVDRIYHIDRGYERIEDKLRALGANIERVKGE
  
Inhibitor
Name:
BDBM119068
Synonyms:
Cpd1 (compound 3)
Type:
Small organic molecule
Emp. Form.:
C21H25NO2
Mol. Mass.:
323.4287
SMILES:
CN(C)CCC(=O)C(OCC=C)(c1ccccc1)c1ccccc1
Structure:
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