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Target
Fatty-acid amide hydrolase 1
Ligand
BDBM143295
Substrate
n/a
Meas. Tech.
FAAH Assay
pH
7.4±n/a
Temperature
298.15±n/a K
IC50
7.00±n/a nM
Comments
extracted
Citation
 Kharul, R; Bhuniya, D; Mookhtiar, KA; Singh, U; Hazare, A; Patil, S; Datrange, L; Thakkar, M Amide compounds, compositions and applications thereof US Patent  US9682953 Publication Date 6/20/2017 
Target
Name:
Fatty-acid amide hydrolase 1
Synonyms:
Anandamide amidohydrolase | Anandamide amidohydrolase 1 | FAAH | FAAH1 | FAAH1_HUMAN | Fatty Acid Amide Hydrolase (FAAH) | Fatty-acid amide hydrolase (FAAH) | Fatty-acid amide hydrolase 1 | Oleamide hydrolase 1
Type:
Protein
Mol. Mass.:
63071.19
Organism:
Homo sapiens (Human)
Description:
O00519
Residue:
579
Sequence:
MVQYELWAALPGASGVALACCFVAAAVALRWSGRRTARGAVVRARQRQRAGLENMDRAAQRFRLQNPDLDSEALLALPLPQLVQKLHSRELAPEAVLFTYVGKAWEVNKGTNCVTSYLADCETQLSQAPRQGLLYGVPVSLKECFTYKGQDSTLGLSLNEGVPAECDSVVVHVLKLQGAVPFVHTNVPQSMFSYDCSNPLFGQTVNPWKSSKSPGGSSGGEGALIGSGGSPLGLGTDIGGSIRFPSSFCGICGLKPTGNRLSKSGLKGCVYGQEAVRLSVGPMARDVESLALCLRALLCEDMFRLDPTVPPLPFREEVYTSSQPLRVGYYETDNYTMPSPAMRRAVLETKQSLEAAGHTLVPFLPSNIPHALETLSTGGLFSDGGHTFLQNFKGDFVDPCLGDLVSILKLPQWLKGLLAFLVKPLLPRLSAFLSNMKSRSAGKLWELQHEIEVYRKTVIAQWRALDLDVVLTPMLAPALDLNAPGRATGAVSYTMLYNCLDFPAGVVPVTTVTAEDEAQMEHYRGYFGDIWDKMLQKGMKKSVGLPVAVQCVALPWQEELCLRFMREVERLMTPEKQSS
  
Inhibitor
Name:
BDBM143295
Synonyms:
US9682953, 5.1
Type:
Small organic molecule
Emp. Form.:
C27H27F3N4O2
Mol. Mass.:
496.5241
SMILES:
CN(C)c1ccc(cn1)C(=O)NC1CCC(CC1)=Cc1cccc(Oc2ccc(cn2)C(F)(F)F)c1 |(13.43,-3.87,;12.1,-3.1,;12.1,-1.56,;10.53,-3.97,;10.53,-5.51,;9.19,-6.28,;7.86,-5.51,;7.86,-3.97,;9.19,-3.2,;6.52,-6.28,;6.52,-7.82,;5.19,-5.51,;3.71,-6.28,;3.71,-7.82,;2.38,-8.59,;1.05,-7.82,;1.05,-6.28,;2.38,-5.51,;-.29,-8.59,;-1.62,-7.82,;-1.62,-6.28,;-2.96,-5.51,;-4.29,-6.28,;-4.29,-7.82,;-5.62,-8.59,;-6.96,-7.82,;-6.96,-6.28,;-8.29,-5.51,;-9.62,-6.28,;-9.62,-7.82,;-8.29,-8.59,;-10.96,-5.51,;-12.29,-6.28,;-10.96,-3.97,;-10.96,-7.05,;-2.96,-8.59,)|
Structure:
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