Reaction Details Report a problem with these data
Target
Protein UL24 homolog
Ligand
BDBM36460
Substrate
n/a
Meas. Tech.
Nuclear Magnetic Resonance (NMR) Assay
pH
8±n/a
IC50
1.5e+3± 3e+2 nM
Comments
extracted
Citation
 Gable, JE; Lee, GM; Jaishankar, P; Hearn, BR; Waddling, CA; Renslo, AR; Craik, CS Broad-spectrum allosteric inhibition of herpesvirus proteases. Biochemistry 53:4648-60 (2014) [PubMed]  Article 
Target
Name:
Protein UL24 homolog
Synonyms:
Kaposi's sarcoma-associated herpesvirus protease (KSHV Pr) | ORF20 | UL24_HHV8P
Type:
Protein
Mol. Mass.:
28447.41
Organism:
Human herpesvirus 8
Description:
Q2HRB2
Residue:
257
Sequence:
MVRPTEAEVKKSLSRLPAARKRAGNRAHLATYRRLLKYSTLPDLWRFLSSRPQNPPLGHHRLFFEVTLGHRIADCVILVSGGHQPVCYVVELKTCLSHQLIPTNTVRTSQRAQGLCQLSDSIHYIAHSAPPGTEAWTITPLLIFKNQKTLKTVYSESPGAFPTPVHTTEGKLCAFLTARENADIRKVLSKVPKKPKMDRGGKILGPTPGKRAVYSQAHHGRNKKGRPWTAQPTRAKSRTKDKGTPAFPRAGPACSGP
  
Inhibitor
Name:
BDBM36460
Synonyms:
3-Benzyl-4-(6-(cyclohexylmethyl)picolinamido)benzoic acid, 2 | CID42628632 | DD2
Type:
Small organic moelcule
Emp. Form.:
C27H28N2O3
Mol. Mass.:
428.5228
SMILES:
OC(=O)c1ccc(NC(=O)c2cccc(CC3CCCCC3)n2)c(Cc2ccccc2)c1
Structure:
Search PDB for entries with ligand similarity: