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Target
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A
Ligand
BDBM8526
Substrate
n/a
Meas. Tech.
Inhibition Assay
pH
8±n/a
IC50
40±n/a nM
Comments
extracted
Citation
 Kaizawa, H; Yamamoto, H; Kamijo, K; Sugita, M; Seo, R; Yamamoto, S; Ukai, A Pyrazoloquinoline compound US Patent  US8822448 Publication Date 9/2/2014 
Target
Name:
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A
Synonyms:
PDE9A_RAT | Pde9a | Phosphodiesterase 9 (PDE9)
Type:
Enzyme
Mol. Mass.:
61749.01
Organism:
Rattus norvegicus (Rat)
Description:
Q8QZV1
Residue:
534
Sequence:
MGAGSSSYRPKAIYLDIDGRIQKVVFSKYCNSSDIMDLFCIATGLPRNTTISLLTTDDAMVSIDPTMPANSERTPYKVRPVAVKQVSEREELVQGVLAQVAEQFSRAFKINELKAEVANHLAMLEKRVELEGLKVVEIEKCKSDIKKMREELAARNNRTNCPCKYSFLDNKKLTPRRDVPTYPKYLLSPETIEALRKPTFDVWLWEPNEMLSCLEHMYHDLGLVRDFSINPITLRRWLLCVHDNYRSNPFHNFRHCFCVTQMMYSMVWLCGLQEKFSQMDILVLMTAAICHDLDHPGYNNTYQINARTELAVRYNDISPLENHHCAIAFQILARPECNIFASVPPEGFRQIRQGMITLILATDMARHAEIMDSFKEKMENFDYSNEEHLTLLKMILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKSEGLPVAPFMDRDKVTKATAQIGFIKFVLIPMFETVTKLFPIVEETMLRPLWESREHYEELKQLDDAMKELQKKTENLTSGATENAPEKTRDAKDNEDRSPPN
  
Inhibitor
Name:
BDBM8526
Synonyms:
CHEMBL1809170 | US8822447, 107 | US8822448, 184 | US9771375, Example 184
Type:
n/a
Emp. Form.:
C20H21N3S
Mol. Mass.:
335.466
SMILES:
CSc1nn(-c2ccc(C)cc2)c2cc(ccc12)C1=CCNCC1 |t:21|
Structure:
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