Target
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A
Ligand
BDBM130711
Substrate
n/a
Meas. Tech.
Inhibition Assay
pH
8±n/a
IC50
0.4±n/a nM
Comments
extracted
Citation
 Kaizawa, HYamamoto, HKamijo, KSugita, MSeo, RYamamoto, SUkai, A Pyrazoloquinoline compound US Patent  US8822448 Publication Date 9/2/2014 
Target
Name:
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A
Synonyms:
PDE9A_RAT | Pde9a | Phosphodiesterase 9 (PDE9)
Type:
Enzyme
Mol. Mass.:
61749.01
Organism:
Rattus norvegicus (Rat)
Description:
Q8QZV1
Residue:
534
Sequence:
MGAGSSSYRPKAIYLDIDGRIQKVVFSKYCNSSDIMDLFCIATGLPRNTTISLLTTDDAMVSIDPTMPANSERTPYKVRPVAVKQVSEREELVQGVLAQVAEQFSRAFKINELKAEVANHLAMLEKRVELEGLKVVEIEKCKSDIKKMREELAARNNRTNCPCKYSFLDNKKLTPRRDVPTYPKYLLSPETIEALRKPTFDVWLWEPNEMLSCLEHMYHDLGLVRDFSINPITLRRWLLCVHDNYRSNPFHNFRHCFCVTQMMYSMVWLCGLQEKFSQMDILVLMTAAICHDLDHPGYNNTYQINARTELAVRYNDISPLENHHCAIAFQILARPECNIFASVPPEGFRQIRQGMITLILATDMARHAEIMDSFKEKMENFDYSNEEHLTLLKMILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKSEGLPVAPFMDRDKVTKATAQIGFIKFVLIPMFETVTKLFPIVEETMLRPLWESREHYEELKQLDDAMKELQKKTENLTSGATENAPEKTRDAKDNEDRSPPN
  
Inhibitor
Name:
BDBM130711
Synonyms:
US8822448, 23
Type:
Small organic molecule
Emp. Form.:
C28H37N5O4
Mol. Mass.:
507.6245
SMILES:
Cc1cc2[nH]c(=O)c3cnn(C4CCOCC4)c3c2cc1C(=O)NCC1(CCCCC1)N1CCOCC1
Structure:
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