Reaction Details
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High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A
Ligand
BDBM130775
Substrate
n/a
Meas. Tech.
Inhibition Assay
pH
8±n/a
IC50
3.7±n/a nM
Comments
extracted
Citation
Kaizawa, H; Yamamoto, H; Kamijo, K; Sugita, M; Seo, R; Yamamoto, S; Ukai, A Pyrazoloquinoline compound US Patent US8822448 Publication Date 9/2/2014 More Info.:
Target
Name:
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A
Synonyms:
PDE9A_RAT | Pde9a | Phosphodiesterase 9 (PDE9)
Type:
Enzyme
Mol. Mass.:
61749.01
Organism:
Rattus norvegicus (Rat)
Description:
Q8QZV1
Residue:
534
Sequence:
MGAGSSSYRPKAIYLDIDGRIQKVVFSKYCNSSDIMDLFCIATGLPRNTTISLLTTDDAMVSIDPTMPANSERTPYKVRPVAVKQVSEREELVQGVLAQVAEQFSRAFKINELKAEVANHLAMLEKRVELEGLKVVEIEKCKSDIKKMREELAARNNRTNCPCKYSFLDNKKLTPRRDVPTYPKYLLSPETIEALRKPTFDVWLWEPNEMLSCLEHMYHDLGLVRDFSINPITLRRWLLCVHDNYRSNPFHNFRHCFCVTQMMYSMVWLCGLQEKFSQMDILVLMTAAICHDLDHPGYNNTYQINARTELAVRYNDISPLENHHCAIAFQILARPECNIFASVPPEGFRQIRQGMITLILATDMARHAEIMDSFKEKMENFDYSNEEHLTLLKMILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKSEGLPVAPFMDRDKVTKATAQIGFIKFVLIPMFETVTKLFPIVEETMLRPLWESREHYEELKQLDDAMKELQKKTENLTSGATENAPEKTRDAKDNEDRSPPN
Inhibitor
Name:
BDBM130775
Synonyms:
US8822448, 202
Type:
Small organic molecule
Emp. Form.:
C25H30N4O4
Mol. Mass.:
450.5301
SMILES:
Cc1cc2[nH]c(=O)c3cnn([C@H]4CCOC4)c3c2cc1C(=O)N1CCC(CC1)OC1CCC1 |r|
Structure:
