Target
G-protein coupled receptor 6
Ligand
BDBM190966
Substrate
n/a
Meas. Tech.
Inhibition of cAMP Activity of GPR6 In Vitro A.2 Assay
IC50
9800±n/a nM
Citation
 Brown, JWHitchcock, SHopkins, MKikuchi, SMonenschein, HReichard, HSchleicher, KSun, HMacklin, T Substituted pyrido[3,4-b]pyrazines as GPR6 modulators US Patent  US10077266 Publication Date 9/18/2018 
Target
Name:
G-protein coupled receptor 6
Synonyms:
G-protein coupled receptor 6 (GPR6) | GPR6 | GPR6_HUMAN | Sphingosine 1-phosphate receptor GPR6
Type:
Protein
Mol. Mass.:
37886.39
Organism:
Homo sapiens (Human)
Description:
P46095
Residue:
362
Sequence:
MNASAASLNDSQVVVVAAEGAAAAATAAGGPDTGEWGPPAAAALGAGGGANGSLELSSQLSAGPPGLLLPAVNPWDVLLCVSGTVIAGENALVVALIASTPALRTPMFVLVGSLATADLLAGCGLILHFVFQYLVPSETVSLLTVGFLVASFAASVSSLLAITVDRYLSLYNALTYYSRRTLLGVHLLLAATWTVSLGLGLLPVLGWNCLAERAACSVVRPLARSHVALLSAAFFMVFGIMLHLYVRICQVVWRHAHQIALQQHCLAPPHLAATRKGVGTLAVVLGTFGASWLPFAIYCVVGSHEDPAVYTYATLLPATYNSMINPIIYAFRNQEIQRALWLLLCGCFQSKVPFRSRSPSEV
  
Inhibitor
Name:
BDBM190966
Synonyms:
US10077266, Example 79 | US9181249, 79 | US9708313, 79
Type:
Small organic molecule
Emp. Form.:
C24H29ClFN5O2
Mol. Mass.:
473.971
SMILES:
CC(C)Nc1nc2CCN(Cc2nc1N1CCC(CC1)C(=O)c1cc(Cl)ccc1F)C(C)=O
Structure:
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