Reaction Details Report a problem with these data
Target
Cannabinoid receptor 2
Ligand
BDBM143559
Substrate
n/a
Meas. Tech.
cAMP Assay
Temperature
300.15±n/a K
EC50
1149±n/a nM
Comments
extracted
Citation
 Macielag, MJ; Zhang, Y; DeCorte, BL; Greco, MN Quinazoline derivatives useful as CB-1 inverse agonists US Patent  US9682955 Publication Date 6/20/2017 
Target
Name:
Cannabinoid receptor 2
Synonyms:
CANNABINOID CB2 | CB-2 | CB2 | CB2A | CB2B | CNR2 | CNR2_HUMAN | CX5 | Cannabinoid CB2 receptor | Cannabinoid receptor 2 (CB2) | Cannabinoid receptor 2 (CB2R) | hCB2
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
39690.94
Organism:
Homo sapiens (Human)
Description:
P34972
Residue:
360
Sequence:
MEECWVTEIANGSKDGLDSNPMKDYMILSGPQKTAVAVLCTLLGLLSALENVAVLYLILSSHQLRRKPSYLFIGSLAGADFLASVVFACSFVNFHVFHGVDSKAVFLLKIGSVTMTFTASVGSLLLTAIDRYLCLRYPPSYKALLTRGRALVTLGIMWVLSALVSYLPLMGWTCCPRPCSELFPLIPNDYLLSWLLFIAFLFSGIIYTYGHVLWKAHQHVASLSGHQDRQVPGMARMRLDVRLAKTLGLVLAVLLICWFPVLALMAHSLATTLSDQVKKAFAFCSMLCLINSMVNPVIYALRSGEIRSSAHHCLAHWKKCVRGLGSEAKEEAPRSSVTETEADGKITPWPDSRDLDLSDC
  
Inhibitor
Name:
BDBM143559
Synonyms:
US9682955, 67
Type:
Small organic molecule
Emp. Form.:
C32H28F2N4
Mol. Mass.:
506.5883
SMILES:
Fc1ccc(cc1)C(c1ccc(F)cc1)c1ccc2ncnc(NC3CCN(CC3)c3ccccc3)c2c1
Structure:
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