Reaction Details Report a problem with these data
Target
C-C chemokine receptor type 2
Ligand
BDBM140239
Substrate
n/a
Meas. Tech.
Radioligand Binding Assay
pH
7.4±n/a
Temperature
277.15±n/a K
Ki
8±n/a nM
IC50
51.8±n/a nM
Comments
extracted
Citation
 Meyer, MD; Wang, X; Guo, T; Wei, RG; Wang, LJ Chemokine receptor antagonists US Patent  US8906911 Publication Date 12/9/2014 
Target
Name:
C-C chemokine receptor type 2
Synonyms:
C-C chemokine receptor type 2 (CCR2) | CCR2 | CCR2_HUMAN | CMKBR2 | Chemoattractant Cytokine Receptor 2 (CCR2) | Chemokine Receptor Type 2b (CCR2b) | Monocyte chemotactic protein-1 (MCP-1)
Type:
Enzyme
Mol. Mass.:
41932.32
Organism:
Homo sapiens (Human)
Description:
P41597
Residue:
374
Sequence:
MLSTSRSRFIRNTNESGEEVTTFFDYDYGAPCHKFDVKQIGAQLLPPLYSLVFIFGFVGNMLVVLILINCKKLKCLTDIYLLNLAISDLLFLITLPLWAHSAANEWVFGNAMCKLFTGLYHIGYFGGIFFIILLTIDRYLAIVHAVFALKARTVTFGVVTSVITWLVAVFASVPGIIFTKCQKEDSVYVCGPYFPRGWNNFHTIMRNILGLVLPLLIMVICYSGILKTLLRCRNEKKRHRAVRVIFTIMIVYFLFWTPYNIVILLNTFQEFFGLSNCESTSQLDQATQVTETLGMTHCCINPIIYAFVGEKFRSLFHIALGCRIAPLQKPVCGGPGVRPGKNVKVTTQGLLDGRGKGKSIGRAPEASLQDKEGA
  
Inhibitor
Name:
BDBM140239
Synonyms:
US8906911, 48
Type:
Small organic molecule
Emp. Form.:
C33H37F3N4O
Mol. Mass.:
562.6683
SMILES:
FC(F)(F)c1ccc(C#N)c(c1)N1C[C@@H]2C[C@H]1CN2C(=O)[C@@]12CCC[C@@H]1C[C@H](C2)N1CCC(CC1)c1ccccc1 |r|
Structure:
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