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Target
Sphingosine 1-phosphate receptor 2
Ligand
BDBM149707
Substrate
n/a
Meas. Tech.
Fluorescence-Based Assay
pH
7.2±n/a
Temperature
310.15±n/a K
IC50
7±n/a nM
Comments
extracted
Citation
 Naganawa, A; Kusumi, K; Otsuki, K; Sekiguchi, T; Kakuuchi, A; Shinozaki, K; Yamamoto, H; Nonaka, S Phenyl derivative US Patent  US8975409 Publication Date 3/10/2015 
Target
Name:
Sphingosine 1-phosphate receptor 2
Synonyms:
EDG5 | S1P2 | S1PR2 | S1PR2_HUMAN | Sphingosine 1-phosphate receptor | Sphingosine 1-phosphate receptor Edg-5 | Sphingosine-1-phosphate receptor 2 | ndothelial differentiation G-protein coupled receptor 5
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
38883.16
Organism:
Homo sapiens (Human)
Description:
Membranes isolated from S1P2-transfected CHO cells were used in ligand binding assay.
Residue:
353
Sequence:
MGSLYSEYLNPNKVQEHYNYTKETLETQETTSRQVASAFIVILCCAIVVENLLVLIAVARNSKFHSAMYLFLGNLAASDLLAGVAFVANTLLSGSVTLRLTPVQWFAREGSAFITLSASVFSLLAIAIERHVAIAKVKLYGSDKSCRMLLLIGASWLISLVLGGLPILGWNCLGHLEACSTVLPLYAKHYVLCVVTIFSIILLAIVALYVRIYCVVRSSHADMAAPQTLALLKTVTIVLGVFIVCWLPAFSILLLDYACPVHSCPILYKAHYFFAVSTLNSLLNPVIYTWRSRDLRREVLRPLQCWRPGVGVQGRRRGGTPGHHLLPLRSSSSLERGMHMPTSPTFLEGNTVV
  
Inhibitor
Name:
BDBM149707
Synonyms:
US8975409, Example 15(1)
Type:
Small organic molecule
Emp. Form.:
C33H40FN3O5
Mol. Mass.:
577.6862
SMILES:
CCNC(=O)c1ccc(Oc2cc(NC(=O)N3CCC(O)(CC(CC)CC)CC3)cc(Oc3ccc(F)cc3)c2)cc1
Structure:
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