Reaction Details Report a problem with these data
Target
2-acylglycerol O-acyltransferase 2
Ligand
BDBM159633
Substrate
n/a
Meas. Tech.
Inhibition Assay
IC50
40±n/a nM
Citation
 Busujima, T; Oi, T; Tanaka, H; Shirasaki, Y; Iwakiri, K; Sato, N; Tokita, S Nitrogen-containing condensed heterocyclic compound US Patent  US9035059 Publication Date 5/19/2015 
Target
Name:
2-acylglycerol O-acyltransferase 2
Synonyms:
2-acylglycerol O-acyltransferase 2 | Acyl-CoA:monoacylglycerol acyltransferase 2 | Acyl-CoA:monoacylglycerol acyltransferase 2 (MOGAT2) | DC5 | DGAT2L5 | Diacylglycerol O-acyltransferase candidate 5 | Diacylglycerol acyltransferase 2-like protein 5 | MGAT2 | MOGAT2 | MOGT2_HUMAN | Monoacylglycerol Acyltransferase 2 (MGAT2) | Monoacylglycerol O-acyltransferase 2 | hDC5 | hMGAT2
Type:
Enzyme
Mol. Mass.:
38210.80
Organism:
Homo sapiens (Human)
Description:
Q3SYC2
Residue:
334
Sequence:
MVEFAPLFMPWERRLQTLAVLQFVFSFLALAEICTVGFIALLFTRFWLLTVLYAAWWYLDRDKPRQGGRHIQAIRCWTIWKYMKDYFPISLVKTAELDPSRNYIAGFHPHGVLAVGAFANLCTESTGFSSIFPGIRPHLMMLTLWFRAPFFRDYIMSAGLVTSEKESAAHILNRKGGGNLLGIIVGGAQEALDARPGSFTLLLRNRKGFVRLALTHGAPLVPIFSFGENDLFDQIPNSSGSWLRYIQNRLQKIMGISLPLFHGRGVFQYSFGLIPYRRPITTVVGKPIEVQKTLHPSEEEVNQLHQRYIKELCNLFEAHKLKFNIPADQHLEFC
  
Inhibitor
Name:
BDBM159633
Synonyms:
US9035059, 6-64
Type:
Small organic molecule
Emp. Form.:
C33H43FN4O2S
Mol. Mass.:
578.784
SMILES:
CC(C)(C)c1cnc(CCN2CCc3cc(ccc3C2)S(=O)(=O)Nc2ccc(CCCC3CCCC3)cc2F)nc1
Structure:
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