Reaction Details Report a problem with these data
Target
5'-AMP-activated protein kinase subunit beta-1
Ligand
BDBM5410
Substrate
n/a
Meas. Tech.
Kinase Assay
IC50
2916±n/a nM
Citation
 Hong, CC; Hopkins, CR; Hatzopoulos, AK; Lindsley, CW; Hao, J Compounds and methods useful for directing stem cell differentiation US Patent  US9040694 Publication Date 5/26/2015 
Target
Name:
5'-AMP-activated protein kinase subunit beta-1
Synonyms:
5'-AMP-activated protein kinase subunit beta-1 | AAKB1_HUMAN | AMP-activated protein kinase alpha-2/beta-1/gamma-3 | AMPK | AMPK subunit beta-1 | AMPKb | PRKAB1
Type:
n/a
Mol. Mass.:
30380.94
Organism:
Homo sapiens (Human)
Description:
Q9Y478
Residue:
270
Sequence:
MGNTSSERAALERHGGHKTPRRDSSGGTKDGDRPKILMDSPEDADLFHSEEIKAPEKEEFLAWQHDLEVNDKAPAQARPTVFRWTGGGKEVYLSGSFNNWSKLPLTRSHNNFVAILDLPEGEHQYKFFVDGQWTHDPSEPIVTSQLGTVNNIIQVKKTDFEVFDALMVDSQKCSDVSELSSSPPGPYHQEPYVCKPEERFRAPPILPPHLLQVILNKDTGISCDPALLPEPNHVMLNHLYALSIKDGVMVLSATHRYKKKYVTTLLYKPI
  
Inhibitor
Name:
BDBM5410
Synonyms:
4-(2-(4-(3-phenylpyrazolo[1,5- a]pyrimidin-6-yl)phenoxy)ethyl)morpholine | 4-[2-(4-{3-phenylpyrazolo[1,5-a]pyrimidin-6-yl}phenoxy)ethyl]morpholine | US9040694, 4 | pyrazolo[1,5-a]pyrimidine 4b
Type:
Small organic molecule
Emp. Form.:
C24H24N4O2
Mol. Mass.:
400.473
SMILES:
C(CN1CCOCC1)Oc1ccc(cc1)-c1cnc2c(cnn2c1)-c1ccccc1
Structure:
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