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Target5-hydroxytryptamine receptor 3A
LigandBDBM160714
Substrate/Competitorn/a
Meas. Tech.Radioligand Binding Assay
pH7.5±n/a
Temperature298.15±n/a K
Ki 6±n/a nM
Commentsextracted
Citation Guzzo, PRManning, DDEarley, W 5-HT3 receptor modulators, methods of making, and use thereof US Patent US9045501 Publication Date 6/2/2015
More Info.:Get all data from this article,  Assay Method
 
5-hydroxytryptamine receptor 3A
Name:Serotonin 3 (5-HT3) receptor
Synonyms:5-HT-3 | 5-HT3 | 5-HT3A | 5-HT3R | 5-hydroxytryptamine receptor 3 (5-HT3) | 5-hydroxytryptamine receptor 3A (5-HT3a) | 5-hydroxytryptamine receptor 3A (5HT3A) | HTR3A | Serotonin 3 (5-HT3) receptor | Serotonin 3 receptor (5HT3) | Serotonin receptor 3A | Serotonin-gated ion channel receptor | Serotonin-gated ion channel receptor 3
Type:Protein
Mol. Mass.:55283.27
Organism:Homo sapiens (Human)
Description:P46098
Residue:478
Sequence:
MLLWVQQALLALLLPTLLAQGEARRSRNTTRPALLRLSDYLLTNYRKGVRPVRDWRKPTT
VSIDVIVYAILNVDEKNQVLTTYIWYRQYWTDEFLQWNPEDFDNITKLSIPTDSIWVPDI
LINEFVDVGKSPNIPYVYIRHQGEVQNYKPLQVVTACSLDIYNFPFDVQNCSLTFTSWLH
TIQDINISLWRLPEKVKSDRSVFMNQGEWELLGVLPYFREFSMESSNYYAEMKFYVVIRR
RPLFYVVSLLLPSIFLMVMDIVGFYLPPNSGERVSFKITLLLGYSVFLIIVSDTLPATAI
GTPLIGVYFVVCMALLVISLAETIFIVRLVHKQDLQQPVPAWLRHLVLERIAWLLCLREQ
STSQRPPATSQATKTDDCSAMGNHCSHMGGPQDFEKSPRDRCSPPPPPREASLAVCGLLQ
ELSSIRQFLEKRDEIREVARDWLRVGSVLDKLLFHIYLLAVLAYSITLVMLWSIWQYA
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  Blast E-value cutoff:
BDBM160714
NameBDBM160714
Synonyms:US9045501, 9
TypeSmall organic molecule
Emp. Form.C17H19FN4O
Mol. Mass.314.3574
SMILESFc1cc2C(=O)N(CCn3ncc(c1)c23)C1CN2CCC1CC2 |(-3.19,-5.12,;-1.85,-4.35,;-1.85,-2.81,;-.52,-2.04,;-.75,-.54,;-2.24,-.14,;.21,.66,;1.75,.66,;2.71,-.54,;2.28,-2.34,;3.19,-3.58,;2.28,-4.83,;.82,-4.35,;-.52,-5.12,;.82,-2.81,;-.19,2.15,;-1.68,2.55,;-2.08,4.04,;-.99,5.12,;.5,4.73,;.9,3.24,;-.59,2.84,;-.59,4.43,)|
Structure
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