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Target
5-hydroxytryptamine receptor 3A
Ligand
BDBM160733
Substrate
n/a
Meas. Tech.
Radioligand Binding Assay
pH
7.5±n/a
Temperature
298.15±n/a K
Ki
24±n/a nM
Comments
extracted
Citation
 Guzzo, PR; Manning, DD; Earley, W 5-HT3 receptor modulators, methods of making, and use thereof US Patent  US9045501 Publication Date 6/2/2015 
Target
Name:
5-hydroxytryptamine receptor 3A
Synonyms:
5-HT-3 | 5-HT3 | 5-HT3A | 5-HT3R | 5-hydroxytryptamine receptor 3 (5-HT3) | 5-hydroxytryptamine receptor 3A (5-HT3a) | 5-hydroxytryptamine receptor 3A (5HT3A) | 5HT3A_HUMAN | 5HT3R | HTR3 | HTR3A | Serotonin 3 (5-HT3) receptor | Serotonin 3 receptor (5HT3) | Serotonin receptor 3A | Serotonin-gated ion channel receptor | Serotonin-gated ion channel receptor 3
Type:
Protein
Mol. Mass.:
55283.27
Organism:
Homo sapiens (Human)
Description:
P46098
Residue:
478
Sequence:
MLLWVQQALLALLLPTLLAQGEARRSRNTTRPALLRLSDYLLTNYRKGVRPVRDWRKPTTVSIDVIVYAILNVDEKNQVLTTYIWYRQYWTDEFLQWNPEDFDNITKLSIPTDSIWVPDILINEFVDVGKSPNIPYVYIRHQGEVQNYKPLQVVTACSLDIYNFPFDVQNCSLTFTSWLHTIQDINISLWRLPEKVKSDRSVFMNQGEWELLGVLPYFREFSMESSNYYAEMKFYVVIRRRPLFYVVSLLLPSIFLMVMDIVGFYLPPNSGERVSFKITLLLGYSVFLIIVSDTLPATAIGTPLIGVYFVVCMALLVISLAETIFIVRLVHKQDLQQPVPAWLRHLVLERIAWLLCLREQSTSQRPPATSQATKTDDCSAMGNHCSHMGGPQDFEKSPRDRCSPPPPPREASLAVCGLLQELSSIRQFLEKRDEIREVARDWLRVGSVLDKLLFHIYLLAVLAYSITLVMLWSIWQYA
  
Inhibitor
Name:
BDBM160733
Synonyms:
US9045501, 30 (Enant. A) | US9045501, 31 (Enant. B)
Type:
Small organic molecule
Emp. Form.:
C17H20N4O
Mol. Mass.:
296.3669
SMILES:
O=C1N(CC2CN3CCC2CC3)Cc2n[nH]c3cccc1c23 |(-3.17,.09,;-1.83,-.68,;-.5,.09,;-.5,1.63,;.59,2.72,;2.08,2.32,;3.17,3.41,;2.77,4.9,;1.28,5.3,;.19,4.21,;1.73,4.21,;1.47,3.17,;1.01,-.62,;.96,-2.37,;1.87,-3.76,;.97,-5,;-.5,-4.53,;-1.83,-5.3,;-3.17,-4.53,;-3.17,-2.99,;-1.83,-2.22,;-.5,-2.99,)|
Structure:
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