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TargetCyclin-dependent kinase 6
LigandBDBM164884
Substrate/Competitorn/a
Meas. Tech. In Vitro Kinase Inhibition Assay
pH7.5±n/a
IC50>5000±n/a nM
Commentsextracted
Citation Zeitlmann, LNiestroj, AHeiser, U Inhibitors of protein kinases US Patent US9067888 Publication Date 6/30/2015
More Info.:Get all data from this article,  Assay Method
 
Cyclin-dependent kinase 6
Name:Cyclin-dependent kinase 6
Synonyms:CDK6 | CDKN6 | Cell division protein kinase 6 | Cyclin-dependent kinase 6 (CDK 6) | Serine/threonine-protein kinase PLSTIRE
Type:Enzyme Subunit
Mol. Mass.:36937.42
Organism:Homo sapiens (Human)
Description:Q00534
Residue:326
Sequence:
MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIR
EVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTE
TIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVV
VTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGE
EDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYF
QDLERCKENLDSHLPPSQNTSELNTA
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  Blast E-value cutoff:
BDBM164884
NameBDBM164884
Synonyms:US9067888, 34
TypeSmall organic molecule
Emp. Form.C20H22FN3O3
Mol. Mass.371.4054
SMILESCOc1cc(F)ccc1-c1ccnc(NC(=O)C2CCC(C2)NC(C)=O)c1
Structure
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