Ki Summary BindingDB logo
myBDB logout
Reaction Details
Report a problem with these data
TargetCDK7/Cyclin H/MNAT1
LigandBDBM164883
Substrate/Competitorn/a
Meas. Tech. In Vitro Kinase Inhibition Assay
pH7.5±n/a
IC50>5000±n/a nM
Commentsextracted
Citation Zeitlmann, LNiestroj, AHeiser, U Inhibitors of protein kinases US Patent US9067888 Publication Date 6/30/2015
More Info.:Get all data from this article,  Assay Method
 
CDK7/Cyclin H/MNAT1
Name:CDK7/Cyclin H/MNAT1
Synonyms:39 kDa protein kinase | CAK1 | CDK-activating kinase | CDK-activating kinase 1 (CAK) | CDK7 | Cell division protein kinase 7 | Cyclin-Dependent Kinase 7 (CDK7) | Cyclin-dependent kinase 7 | Cyclin-dependent kinase 7 (CDK7/cyclin H) | P39 Mo15 | STK1 | TFIIH basal transcription factor complex kinase subunit
Type:Enzyme Subunit
Mol. Mass.:39047.01
Organism:Homo sapiens (Human)
Description:n/a
Residue:346
Sequence:
MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTAL
REIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLM
TLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRA
PELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDM
CSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPG
PTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM164883
NameBDBM164883
Synonyms:US9067888, 33
TypeSmall organic molecule
Emp. Form.C21H24FN3O3
Mol. Mass.385.432
SMILESCOc1cc(F)ccc1-c1ccnc(NC(=O)[C@H]2CCC[C@H](C2)NC(C)=O)c1 |r|
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least:
n/a