Reaction Details Report a problem with these data
Target
Glutaminyl-peptide cyclotransferase
Ligand
BDBM179606
Substrate
n/a
Meas. Tech.
Fluorometric Assay
pH
8±n/a
Temperature
303.15±n/a K
Ki
690±n/a nM
IC50
8670±n/a nM
Comments
extracted
Citation
 Heiser, U; Ramsbeck, D; Buchholz, M; Niestroj, AJ Inhibitors of glutaminyl cyclase US Patent  US9126987 Publication Date 9/8/2015 
Target
Name:
Glutaminyl-peptide cyclotransferase
Synonyms:
Glutaminyl Cyclase | Glutaminyl cyclase (QC) | Glutaminyl-peptide cyclotransferase | Glutaminyl-peptide cyclotransferase precursor (QC) | Glutaminyl-tRNA cyclotransferase | Glutamyl cyclase (QC) | QPCT | QPCT_HUMAN
Type:
Enzyme
Mol. Mass.:
40877.05
Organism:
Homo sapiens (Human)
Description:
Q16769
Residue:
361
Sequence:
MAGGRHRRVVGTLHLLLLVAALPWASRGVSPSASAWPEEKNYHQPAILNSSALRQIAEGTSISEMWQNDLQPLLIERYPGSPGSYAARQHIMQRIQRLQADWVLEIDTFLSQTPYGYRSFSNIISTLNPTAKRHLVLACHYDSKYFSHWNNRVFVGATDSAVPCAMMLELARALDKKLLSLKTVSDSKPDLSLQLIFFDGEEAFLHWSPQDSLYGSRHLAAKMASTPHPPGARGTSQLHGMDLLVLLDLIGAPNPTFPNFFPNSARWFERLQAIEHELHELGLLKDHSLEGRYFQNYSYGGVIQDDHIPFLRRGVPVLHLIPSPFPEVWHTMDDNEENLDESTIDNLNKILQVFVLEYLHL
  
Inhibitor
Name:
BDBM179606
Synonyms:
US9126987, 5
Type:
Small organic molecule
Emp. Form.:
C20H14N4OS
Mol. Mass.:
358.416
SMILES:
C(Sc1nnc(o1)-c1ccc2[nH]cnc2c1)c1ccc2ccccc2c1
Structure:
Search PDB for entries with ligand similarity: