Reaction Details
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Lysosomal protective protein [29-480]
Ligand
BDBM183928
Substrate
n/a
Meas. Tech.
Inhibition Assay
pH
6±n/a
Temperature
310.15±n/a K
IC50
343±n/a nM
Comments
extracted
Citation
Ruf, S; Sadowski, T; Wirth, K; Schreuder, H; Buning, C; Kallus, C; Strobel, H; Wehlan, H Biaryl-propionic acid derivatives and their use as pharmaceuticals US Patent US9150526 Publication Date 10/6/2015 More Info.:
Target
Name:
Lysosomal protective protein [29-480]
Synonyms:
CTSA | Cathepsin A | Cathepsin A (CTSA) | PPGB | PPGB_HUMAN
Type:
n/a
Mol. Mass.:
51408.15
Organism:
Homo sapiens (Human)
Description:
P10619[29-480]
Residue:
452
Sequence:
APDQDEIQRLPGLAKQPSFRQYSGYLKGSGSKHLHYWFVESQKDPENSPVVLWLNGGPGCSSLDGLLTEHGPFLVQPDGVTLEYNPYSWNLIANVLYLESPAGVGFSYSDDKFYATNDTEVAQSNFEALQDFFRLFPEYKNNKLFLTGESYAGIYIPTLAVLVMQDPSMNLQGLAVGNGLSSYEQNDNSLVYFAYYHGLLGNRLWSSLQTHCCSQNKCNFYDNKDLECVTNLQEVARIVGNSGLNIYNLYAPCAGGVPSHFRYEKDTVVVQDLGNIFTRLPLKRMWHQALLRSGDKVRMDPPCTNTTAASTYLNNPYVRKALNIPEQLPQWDMCNFLVNLQYRRLYRSMNSQYLKLLSSQKYQILLYNGDVDMACNFMGDEWFVDSLNQKMEVQRRPWLVKYGDSGEQIAGFVKEFSHIAFLTIKGAGHMVPTDKPLAAFTMFSRFLNKQPY
Inhibitor
Name:
BDBM183928
Synonyms:
US9150526, 186
Type:
Small organic molecule
Emp. Form.:
C20H21N3O5
Mol. Mass.:
383.3978
SMILES:
COc1cc(C)cc(OC)c1-c1cncc(c1)C(CC(O)=O)c1nnc(C)o1
Structure:
