Reaction Details
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Cell division cycle 7-related protein kinase
Ligand
BDBM185849
Substrate
n/a
Meas. Tech.
Inhibition Assay
pH
7.5±n/a
Ki
3.4±n/a nM
Comments
extracted
Citation
Akritopoulou-Zanze, I; Wakefield, BD; Mack, H; Turner, SC; Gasiecki, AF; Gracias, VJ; Sarris, KA; Kalvin, DM; Michmerhuizen, MJ; Shuai, Q; Patel, JR; Bakker, MH; Teusch, N; Johnson, EF; Kovar, PJ; Djuric, SW; Long, AJ; Vasudevan, A; George, DM; Wang, L; Li, B; Moore, NS; Hobson, AD; Woods, KW; Miyashiro, JM; Swann, Jr., SL; Penning, TD 5-substituted indazoles as kinase inhibitors US Patent US9163007 Publication Date 10/20/2015 More Info.:
Target
Name:
Cell division cycle 7-related protein kinase
Synonyms:
CDC7 | CDC7-related kinase | CDC7L1 | CDC7_HUMAN | Cell division cycle 7-related protein kinase (CDC7) | HsCdc7 | huCdc7
Type:
Protein
Mol. Mass.:
63908.16
Organism:
Homo sapiens (Human)
Description:
O00311
Residue:
574
Sequence:
MEASLGIQMDEPMAFSPQRDRFQAEGSLKKNEQNFKLAGVKKDIEKLYEAVPQLSNVFKIEDKIGEGTFSSVYLATAQLQVGPEEKIALKHLIPTSHPIRIAAELQCLTVAGGQDNVMGVKYCFRKNDHVVIAMPYLEHESFLDILNSLSFQEVREYMLNLFKALKRIHQFGIVHRDVKPSNFLYNRRLKKYALVDFGLAQGTHDTKIELLKFVQSEAQQERCSQNKSHIITGNKIPLSGPVPKELDQQSTTKASVKRPYTNAQIQIKQGKDGKEGSVGLSVQRSVFGERNFNIHSSISHESPAVKLMKQSKTVDVLSRKLATKKKAISTKVMNSAVMRKTASSCPASLTCDCYATDKVCSICLSRRQQVAPRAGTPGFRAPEVLTKCPNQTTAIDMWSAGVIFLSLLSGRYPFYKASDDLTALAQIMTIRGSRETIQAAKTFGKSILCSKEVPAQDLRKLCERLRGMDSSTPKLTSDIQGHASHQPAISEKTDHKASCLVQTPPGQYSGNSFKKGDSNSCEHCFDEYNTNLEGWNEVPDEAYDLLDKLLDLNPASRITAEEALLHPFFKDMSL
Inhibitor
Name:
BDBM185849
Synonyms:
US9163007, 163
Type:
Small organic molecule
Emp. Form.:
C23H20N6
Mol. Mass.:
380.4451
SMILES:
Cc1ccccc1-c1c(nnn1Cc1ccccc1)-c1ccc2[nH]nc(N)c2c1 |(11.93,-1.26,;10.78,-.23,;11.1,1.27,;9.96,2.3,;8.49,1.83,;8.17,.32,;9.32,-.71,;9,-2.22,;7.59,-2.84,;7.75,-4.37,;9.26,-4.69,;10.03,-3.36,;11.56,-3.2,;12.47,-4.45,;14,-4.28,;14.9,-5.53,;14.28,-6.94,;12.74,-7.1,;11.84,-5.85,;6.26,-2.07,;6.26,-.53,;4.92,.24,;3.59,-.53,;2.13,-.06,;1.22,-1.3,;2.13,-2.55,;1.65,-4.01,;3.59,-2.07,;4.92,-2.84,)|
Structure:
