Reaction Details Report a problem with these data
Target
D-amino-acid oxidase
Ligand
BDBM190377
Substrate
n/a
Meas. Tech.
Enzyme Assay
IC50
79±n/a nM
Citation
 Farnaby, W; Fieldhouse, C; Kerr, C; Kinsella, N; Livermore, D; Merchant, K; Miller, D; Hazel, K 5- or 6-substituted 3-hydroxy-2 (1 H)-pyridinones as D-amino acid oxidase (DAAO) inhibitors in therapy of diseases such as schizophrenia, cognitive disorder and pain US Patent  US9180122 Publication Date 11/10/2015 
Target
Name:
D-amino-acid oxidase
Synonyms:
D-amino-acid oxidase (DAAO) | DAAO | DAMOX | DAO | OXDA_HUMAN
Type:
Homodimer
Mol. Mass.:
39476.06
Organism:
Homo sapiens (Human)
Description:
P14920
Residue:
347
Sequence:
MRVVVIGAGVIGLSTALCIHERYHSVLQPLDIKVYADRFTPLTTTDVAAGLWQPYLSDPNNPQEADWSQQTFDYLLSHVHSPNAENLGLFLISGYNLFHEAIPDPSWKDTVLGFRKLTPRELDMFPDYGYGWFHTSLILEGKNYLQWLTERLTERGVKFFQRKVESFEEVAREGADVIVNCTGVWAGALQRDPLLQPGRGQIMKVDAPWMKHFILTHDPERGIYNSPYIIPGTQTVTLGGIFQLGNWSELNNIQDHNTIWEGCCRLEPTLKNARIIGERTGFRPVRPQIRLEREQLRTGPSNTEVIHNYGHGGYGLTIHWGCALEAAKLFGRILEEKKLSRMPPSHL
  
Inhibitor
Name:
BDBM190377
Synonyms:
US9180122, 12
Type:
Small organic molecule
Emp. Form.:
C14H15NO2S
Mol. Mass.:
261.339
SMILES:
CCc1ccc(CSc2c[nH]c(=O)c(O)c2)cc1
Structure:
Search PDB for entries with ligand similarity: