Reaction Details Report a problem with these data
Target
Enoyl-[acyl-carrier-protein] reductase [NADH]
Ligand
BDBM16296
Substrate
n/a
Meas. Tech.
Inhibition Kinetics
IC50
1e+3±n/a nM
Citation
 Neckles, C; Pschibul, A; Lai, CT; Hirschbeck, M; Kuper, J; Davoodi, S; Zou, J; Liu, N; Pan, P; Shah, S; Daryaee, F; Bommineni, GR; Lai, C; Simmerling, C; Kisker, C; Tonge, PJ Selectivity of Pyridone- and Diphenyl Ether-Based Inhibitors for the Yersinia pestis FabV Enoyl-ACP Reductase. Biochemistry 55:2992-3006 (2016) [PubMed]  Article 
Target
Name:
Enoyl-[acyl-carrier-protein] reductase [NADH]
Synonyms:
Enoyl-ACP reductase (Wt ypFabV) | FABV_YERPE | fabV
Type:
Protein
Mol. Mass.:
43335.99
Organism:
Yersinia pestis (Enterobacteria)
Description:
n/a
Residue:
399
Sequence:
MIIKPRVRGFICVTAHPTGCEANVKKQIDYVTTEGPIANGPKRVLVIGASTGYGLAARITAAFGCGADTLGVFFERPGEEGKPGTSGWYNSAAFHKFAAQKGLYAKSINGDAFSDEIKQLTIDAIKQDLGQVDQVIYSLASPRRTHPKTGEVFNSALKPIGNAVNLRGLDTDKEVIKESVLQPATQSEIDSTVAVMGGEDWQMWIDALLDAGVLAEGAQTTAFTYLGEKITHDIYWNGSIGAAKKDLDQKVLAIRESLAAHGGGDARVSVLKAVVTQASSAIPMMPLYLSLLFKVMKEKGTHEGCIEQVYSLYKDSLCGDSPHMDQEGRLRADYKELDPEVQNQVQQLWDQVTNDNIYQLTDFVGYKSEFLNLFGFGIDGVDYDADVNPDVKIPNLIQG
  
Inhibitor
Name:
BDBM16296
Synonyms:
5-Pentyl-2-phenoxy-phenol | 5-pentyl-2-phenoxylphenol | 5-pentyl-2-phenoxyphenol | 5PP | AIDS227445 | PT03
Type:
Small organic molecule
Emp. Form.:
C17H20O2
Mol. Mass.:
256.3395
SMILES:
CCCCCc1ccc(Oc2ccccc2)c(O)c1
Structure:
Search PDB for entries with ligand similarity: