Reaction Details
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Adenosine receptor A3 [I248L]
Ligand
BDBM191066
Substrate
n/a
Meas. Tech.
Radioligand Binding Assay
pH
7.5±n/a
Temperature
298.15±n/a K
Ki
40.4±13.1 nM
Comments
extracted
Citation
Jacobson, KA; Tosh, DK Adenosine receptor agonists, partial agonists, and antagonists US Patent US9181253 Publication Date 11/10/2015 More Info.:
Target
Name:
Adenosine receptor A3 [I248L]
Synonyms:
AA3R_HUMAN | ADORA3 | Adenosine receptor A3 | Adenosine receptor A3 (A3)
Type:
Protein
Mol. Mass.:
36197.32
Organism:
Homo sapiens (Human)
Description:
P0DMS8[I248L]
Residue:
318
Sequence:
MPNNSTALSLANVTYITMEIFIGLCAIVGNVLVICVVKLNPSLQTTTFYFIVSLALADIAVGVLVMPLAIVVSLGITIHFYSCLFMTCLLLIFTHASIMSLLAIAVDRYLRVKLTVRYKRVTTHRRIWLALGLCWLVSFLVGLTPMFGWNMKLTSEYHRNVTFLSCQFVSVMRMDYMVYFSFLTWIFIPLVVMCAIYLDIFYIIRNKLSLNLSNSKETGAFYGREFKTAKSLFLVLFLFALSWLPLSLINCIIYFNGEVPQLVLYMGILLSHANSMMNPIVYAYKIKKFKETYLLILKACVVCHPSDSLDTSIEKNSE
Inhibitor
Name:
BDBM191066
Synonyms:
US9181253, 128
Type:
Small organic molecule
Emp. Form.:
C19H18ClF2N5O3
Mol. Mass.:
437.828
SMILES:
OCc1cc(F)c(F)cc1CNc1nc(Cl)nc2n(cnc12)[C@]12C[C@H]1[C@@H](O)[C@@H](O)C2 |r|
Structure:
