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Target
5'-AMP-activated protein kinase catalytic subunit alpha-1
Ligand
BDBM192510
Substrate
n/a
Meas. Tech.
AMPK Activation Assay
pH
7±n/a
EC50
6±n/a nM
Citation
 Wagner, H; Himmelsbach, F Azabenzimidazole derivatives US Patent  US9187477 Publication Date 11/17/2015 
Target
Name:
5'-AMP-activated protein kinase catalytic subunit alpha-1
Synonyms:
AAPK1_HUMAN | ACACA kinase | AMP-activated protein kinase alpha-1/beta-2/gamma-2 | AMP-activated protein kinase, alpha-1 subunit | AMPK subunit alpha-1 | AMPK-alpha1 | AMPK1 | Hydroxymethylglutaryl-CoA reductase kinase | PRKAA1 | Tau-protein kinase PRKAA1
Type:
Protein
Mol. Mass.:
64023.62
Organism:
Homo sapiens (Human)
Description:
Q13131
Residue:
559
Sequence:
MRRLSSWRKMATAEKQKHDGRVKIGHYILGDTLGVGTFGKVKVGKHELTGHKVAVKILNRQKIRSLDVVGKIRREIQNLKLFRHPHIIKLYQVISTPSDIFMVMEYVSGGELFDYICKNGRLDEKESRRLFQQILSGVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSSGVILYALLCGTLPFDDDHVPTLFKKICDGIFYTPQYLNPSVISLLKHMLQVDPMKRATIKDIREHEWFKQDLPKYLFPEDPSYSSTMIDDEALKEVCEKFECSEEEVLSCLYNRNHQDPLAVAYHLIIDNRRIMNEAKDFYLATSPPDSFLDDHHLTRPHPERVPFLVAETPRARHTLDELNPQKSKHQGVRKAKWHLGIRSQSRPNDIMAEVCRAIKQLDYEWKVVNPYYLRVRRKNPVTSTYSKMSLQLYQVDSRTYLLDFRSIDDEITEAKSGTATPQRSGSVSNYRSCQRSDSDAEAQGKSSEVSLTSSVTSLDSSPVDLTPRPGSHTIEFFEMCANLIKILAQ
  
Inhibitor
Name:
BDBM192510
Synonyms:
US9187477, 6
Type:
Small organic molecule
Emp. Form.:
C29H33ClN4O7
Mol. Mass.:
585.048
SMILES:
O[C@@H]1COC2[C@@H](COC12)Oc1nc2cc(Cl)c(nc2[nH]1)-c1ccc(cc1)[C@H]1CC[C@@H](CC1)OC(=O)N1CCOCC1 |r,wU:26.30,5.10,1.0,wD:29.37,(13.03,-6.2,;12.26,-4.87,;12.73,-3.4,;11.49,-2.5,;10.24,-3.4,;8.7,-3.4,;8.23,-4.87,;9.47,-5.77,;10.72,-4.87,;7.93,-2.07,;6.39,-2.07,;5.49,-3.31,;4.02,-2.84,;2.69,-3.61,;1.35,-2.84,;.02,-3.61,;1.35,-1.3,;2.69,-.53,;4.02,-1.3,;5.49,-.82,;.02,-.53,;.02,1.01,;-1.31,1.78,;-2.65,1.01,;-2.65,-.53,;-1.31,-1.3,;-3.69,1.73,;-5.03,.96,;-6.36,1.73,;-6.36,3.27,;-5.03,4.04,;-3.69,3.27,;-7.69,4.04,;-9.03,3.27,;-9.03,1.73,;-10.36,4.04,;-11.69,3.27,;-13.03,4.04,;-13.03,5.58,;-11.69,6.35,;-10.36,5.58,)|
Structure:
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