Target
Lysine-specific demethylase 4C [1-350]
Ligand
BDBM195609
Substrate
n/a
Meas. Tech.
KDM4C Enzymatic Screening Assay
pH
7.5±n/a
IC50
3.0e+3±n/a nM
Comments
extracted
Citation
 Vinogradova, MGehling, VSGustafson, AArora, STindell, CAWilson, CWilliamson, KEGuler, GDGangurde, PManieri, WBusby, JFlynn, EMLan, FKim, HJOdate, SCochran, AGLiu, YWongchenko, MYang, YCheung, TKMaile, TMLau, TCosta, MHegde, GVJackson, EPitti, RArnott, DBailey, CBellon, SCummings, RTAlbrecht, BKHarmange, JCKiefer, JRTrojer, PClasson, M An inhibitor of KDM5 demethylases reduces survival of drug-tolerant cancer cells. Nat Chem Biol 12:531-8 (2016) [PubMed]  Article 
Target
Name:
Lysine-specific demethylase 4C [1-350]
Synonyms:
GASC1 | JHDM3C | JMJD2C | KDM4C | KDM4C_HUMAN | KIAA0780 | Lysine-specific demethylase 4C (KDM4C)
Type:
Protein
Mol. Mass.:
40626.08
Organism:
Homo sapiens (Human)
Description:
Q9H3R0; His-tagged recombinant KDM4C (1-350) overexpressed in E. coli(DE3)
Residue:
350
Sequence:
MEVAEVESPLNPSCKIMTFRPSMEEFREFNKYLAYMESKGAHRAGLAKVIPPKEWKPRQCYDDIDNLLIPAPIQQMVTGQSGLFTQYNIQKKAMTVKEFRQLANSGKYCTPRYLDYEDLERKYWKNLTFVAPIYGADINGSIYDEGVDEWNIARLNTVLDVVEEECGISIEGVNTPYLYFGMWKTTFAWHTEDMDLYSINYLHFGEPKSWYAIPPEHGKRLERLAQGFFPSSSQGCDAFLRHKMTLISPSVLKKYGIPFDKITQEAGEFMITFPYGYHAGFNHGFNCAESTNFATVRWIDYGKVAKLCTCRKDMVKISMDIFVRKFQPDRYQLWKQGKDIYTIDHTKPTP
  
Inhibitor
Name:
BDBM195609
Synonyms:
CPI-4203
Type:
Small organic molecule
Emp. Form.:
C16H14N4O
Mol. Mass.:
278.3086
SMILES:
CCc1c([nH]c2c(cnn2c1=O)C#N)-c1ccccc1C
Structure:
Search PDB for entries with ligand similarity: