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Target
Endothelial lipase
Ligand
BDBM199225
Substrate
n/a
Meas. Tech.
Endothelial Lipase Assay
pH
7.2±n/a
IC50
4±n/a nM
Comments
extracted
Citation
 Connelly, MA; Greco, M; Ye, H Tricyclic indole derivatives useful endothelial lipase inhibitors US Patent  US9216998 Publication Date 12/22/2015 
Target
Name:
Endothelial lipase
Synonyms:
EDL | Endothelial cell-derived lipase | Endothelial lipase | Endothelial lipase (EL) | LIPE_MOUSE | Lipg
Type:
Protein
Mol. Mass.:
56643.58
Organism:
Mus musculus (Mouse)
Description:
Q9WVG5
Residue:
500
Sequence:
MRNTVFLLGFWSVYCYFPAGSITTLRPQGSLRDEHHKPTGVPATARPSVAFNIRTSKDPEQEGCNLSLGDSKLLENCGFNMTAKTFFIIHGWTMSGMFESWLHKLVSALQMREKDANVVVVDWLPLAHQLYTDAVNNTRVVGQRVAGMLDWLQEKEEFSLGNVHLIGYSLGAHVAGYAGNFVKGTVGRITGLDPAGPMFEGVDINRRLSPDDADFVDVLHTYTLSFGLSIGIRMPVGHIDIYPNGGDFQPGCGFNDVIGSFAYGTISEMVKCEHERAVHLFVDSLVNQDKPSFAFQCTDSSRFKRGICLSCRKNRCNNIGYNAKKMRKKRNSKMYLKTRAGMPFKVYHYQLKVHMFSYNNSGDTQPTLYITLYGSNADSQNLPLEIVEKIELNATNTFLVYTEEDLGDLLKMRLTWEGVAHSWYNLWNEFRNYLSQPSNPSRELYIRRIRVKSGETQRKVTFCTQDPTKSSISPGQELWFHKCQDGWKMKNKTSPFVNLA
  
Inhibitor
Name:
BDBM199225
Synonyms:
US9216998, 8
Type:
Small organic molecule
Emp. Form.:
C21H21F3N2O
Mol. Mass.:
374.3994
SMILES:
Nc1cc2CCCn3c(CCCOc4ccccc4)c(c(c1)c23)C(F)(F)F
Structure:
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