Target
Aldo-keto reductase family 1 member B10 [K125R,V301L]
Ligand
BDBM200220
Substrate
n/a
Meas. Tech.
IC50-Activity Assay (AR)
pH
7±n/a
IC50
1.0e+3±n/a nM
Comments
extracted
Citation
 Cousido-Siah, ARuiz, FXFranflík, JGiménez-Dejoz, JMitschler, AKamlar, MVesely´, JAjani, HParés, XFarrés, JHobza, PPodjarny, AD IDD388 Polyhalogenated Derivatives as Probes for an Improved Structure-Based Selectivity of AKR1B10 Inhibitors ACS Chem Biol 11:2693-2705 (2016) [PubMed]  Article 
Target
Name:
Aldo-keto reductase family 1 member B10 [K125R,V301L]
Synonyms:
AK1BA_HUMAN | AKR1B10 | AKR1B11 | Methylated AKR1B10 K125R/V301L (AKME2MU)
Type:
Protein
Mol. Mass.:
36066.71
Organism:
Homo sapiens (Human)
Description:
Methylated form of AKR1B10 with mutations K125R and V301L; 4XLJ; 4XLK; 4XM9; 4XLM; 4XMJ; 4XZL; 4WEV
Residue:
316
Sequence:
MATFVELSTKAKMPIVGLGTWKSPLGKVKEAVKVAIDAGYRHIDCAYVYQNEHEVGEAIQEKIQEKAVKREDLFIVSKLWPTFFERPLVRKAFEKTLKDLKLSYLDVYLIHWPQGFKSGDDLFPRDDKGNAIGGKATFLDAWEAMEELVDEGLVKALGVSNFSHFQIEKLLNKPGLKYKPVTNQVECHPYLTQEKLIQYCHSKGITVTAYSPLGSPDRPWAKPEDPSLLEDPKIKEIAAKHKKTAAQVLIRFHIQRNVIVIPKSVTPARIVENIQVFDFKLSDEEMATILSFNRNWRACNLLQSSHLEDYPFNAEY
  
Inhibitor
Name:
BDBM200220
Synonyms:
2-(5-chloro-2-((2,4,6-tribromobenzyl)carbamoyl)phenoxy)acetic acid | MK184
Type:
Small organic molecule
Emp. Form.:
C16H11Br3ClNO4
Mol. Mass.:
556.428
SMILES:
OC(=O)COc1cc(Cl)ccc1C(=O)NCc1c(Br)cc(Br)cc1Br
Structure:
Search PDB for entries with ligand similarity: