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Target
Aldo-keto reductase family 1 member B1 [L301M]
Ligand
BDBM16312
Substrate
n/a
Meas. Tech.
IC50-Activity Assay (AR)
pH
7±n/a
IC50
5.0e+2±n/a nM
Comments
extracted
Citation
Cousido-Siah, A; Ruiz, FX; Franflík, J; Giménez-Dejoz, J; Mitschler, A; Kamlar, M; Vesely´, J; Ajani, H; Parés, X; Farrés, J; Hobza, P; Podjarny, AD IDD388 Polyhalogenated Derivatives as Probes for an Improved Structure-Based Selectivity of AKR1B10 Inhibitors ACS Chem Biol 11:2693-2705 (2016) [PubMed] Article
More Info.:
Target
Name:
Aldo-keto reductase family 1 member B1 [L301M]
Synonyms:
AKR1B1 | ALDR1 | ALDR_HUMAN | ALR2 | Aldose reductase L301M (AR)
Type:
Protein
Mol. Mass.:
35873.53
Organism:
Homo sapiens (Human)
Description:
P15121 with one mutation L301M. 2PDK
Residue:
316
Sequence:
MASRLLLNNGAKMPILGLGTWKSPPGQVTEAVKVAIDVGYRHIDCAHVYQNENEVGVAIQEKLREQVVKREELFIVSKLWCTYHEKGLVKGACQKTLSDLKLDYLDLYLIHWPTGFKPGKEFFPLDESGNVVPSDTNILDTWAAMEELVDEGLVKAIGISNFNHLQVEMILNKPGLKYKPAVNQIECHPYLTQEKLIQYCQSKGIVVTAYSPLGSPDRPWAKPEDPSLLEDPRIKAIAAKHNKTTAQVLIRFPMQRNLVVIPKSVTPERIAENFKVFDFELSSQDMTTLLSYNRNWRVCAMLSCTSHKDYPFHEEF