Target
Orexin/Hypocretin receptor type 1
Ligand
BDBM203192
Substrate
n/a
Meas. Tech.
In Vitro Assay: Intracellular Calcium Measurements
Temperature
310.15±n/a K
IC50
976±n/a nM
Comments
extracted
Citation
 Aissaoui, HBoss, CBrotschi, CHeidmann, BSifferlen, TWilliams, JT Lactam derivatives useful as orexin receptor antagonists US Patent  US9242970 Publication Date 1/26/2016 
Target
Name:
Orexin/Hypocretin receptor type 1
Synonyms:
HCRTR1 | Hypocretin receptor type 1 | OX1R_HUMAN | Orexin receptor type 1 | Orexin receptor type 1 (OR 1) | Orexin receptor type 1 (OR-1) | Orexin receptor type 1 (OX1) | Orexin receptor type 1 (OX1R) | Orexin receptor type 1 (OxR1) | Ox1r
Type:
Protein
Mol. Mass.:
47554.50
Organism:
Homo sapiens (Human)
Description:
O43613
Residue:
425
Sequence:
MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP
  
Inhibitor
Name:
BDBM203192
Synonyms:
US9242970, 374
Type:
Small organic molecule
Emp. Form.:
C21H22F3NO3
Mol. Mass.:
393.3995
SMILES:
CCOc1cccc(F)c1C1CC(C)C(=O)N1Cc1cccc(OC(F)F)c1
Structure:
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