Reaction Details Report a problem with these data
Target
Bromodomain-containing protein 2 [71-194]
Ligand
BDBM205431
Substrate
n/a
Meas. Tech.
Bromodomains Assay for DiscoveRx Gene Symbol
Ki
0.014±0.0 nM
Citation
 Tanaka, M; Roberts, JM; Seo, HS; Souza, A; Paulk, J; Scott, TG; DeAngelo, SL; Dhe-Paganon, S; Bradner, JE Design and characterization of bivalent BET inhibitors. Nat Chem Biol 12:1089-1096 (2016) [PubMed]  Article 
Target
Name:
Bromodomain-containing protein 2 [71-194]
Synonyms:
BET bromodomain 2(1) (BRD2(1)) | BRD2 | BRD2_HUMAN | KIAA9001 | RING3
Type:
n/a
Mol. Mass.:
14684.56
Organism:
Homo sapiens (Human)
Description:
P25440 (BRD2, 71-194)
Residue:
124
Sequence:
KPGRVTNQLQYLHKVVMKALWKHQFAWPFRQPVDAVKLGLPDYHKIIKQPMDMGTIKRRLENNYYWAASECMQDFNTMFTNCYIYNKPTDDIVLMAQTLEKIFLQKVASMPQEEQELVVTIPKN
  
Inhibitor
Name:
BDBM205431
Synonyms:
(6S+2S)-PEG1 (7)
Type:
Small organic molecule
Emp. Form.:
C43H42Cl2N10O5S2
Mol. Mass.:
913.894
SMILES:
COC(=O)C[C@@H]1N=C(c2c(C)c(sc2-n2c(C)nnc12)C(=O)NCCOCCNC(=O)C[C@@H]1N=C(c2c(C)c(C)sc2-n2c(C)nnc12)c1ccc(Cl)cc1)c1ccc(Cl)cc1 |r,c:6,36|
Structure:
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