Target
Bromodomain-containing protein 4 [44-168,333-460]
Ligand
BDBM205431
Substrate
n/a
Meas. Tech.
Bromodomains Assay for DiscoveRx Gene Symbol
Ki
0.012±0.0 nM
Citation
 Tanaka, MRoberts, JMSeo, HSSouza, APaulk, JScott, TGDeAngelo, SLDhe-Paganon, SBradner, JE Design and characterization of bivalent BET inhibitors. Nat Chem Biol 12:1089-1096 (2016) [PubMed]  Article 
Target
Name:
Bromodomain-containing protein 4 [44-168,333-460]
Synonyms:
BET bromodomain 4(1,2) (BRD4(1,2)) | BRD4 | BRD4_HUMAN | HUNK1
Type:
n/a
Mol. Mass.:
29666.85
Organism:
Homo sapiens (Human)
Description:
O60885 (BRD4, 44-168 and 333-460)
Residue:
253
Sequence:
NPPPPETSNPNKPKRQTNQLQYLLRVVLKTLWKHQFAWPFQQPVDAVKLNLPDYYKIIKTPMDMGTIKKRLENNYYWNAQECIQDFNTMFTNCYIYNKPGDDIVLMAEALEKLFLQKINELPTEEKDVPDSQQHPAPEKSSKVSEQLKCCSGILKEMFAKKHAAYAWPFYKPVDVEALGLHDYCDIIKHPMDMSTIKSKLEAREYRDAQEFGADVRLMFSNCYKYNPPDHEVVAMARKLQDVFEMRFAKMPDE
  
Inhibitor
Name:
BDBM205431
Synonyms:
(6S+2S)-PEG1 (7)
Type:
Small organic molecule
Emp. Form.:
C43H42Cl2N10O5S2
Mol. Mass.:
913.894
SMILES:
COC(=O)C[C@@H]1N=C(c2c(C)c(sc2-n2c(C)nnc12)C(=O)NCCOCCNC(=O)C[C@@H]1N=C(c2c(C)c(C)sc2-n2c(C)nnc12)c1ccc(Cl)cc1)c1ccc(Cl)cc1 |r,c:6,36|
Structure:
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