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Target
Bromodomain-containing protein 4 [44-168,333-460]
Ligand
BDBM205453
Substrate
n/a
Meas. Tech.
Bromodomains Assay for DiscoveRx Gene Symbol
Ki
0.087±0.0 nM
Citation
 Tanaka, M; Roberts, JM; Seo, HS; Souza, A; Paulk, J; Scott, TG; DeAngelo, SL; Dhe-Paganon, S; Bradner, JE Design and characterization of bivalent BET inhibitors. Nat Chem Biol 12:1089-1096 (2016) [PubMed]  Article 
Target
Name:
Bromodomain-containing protein 4 [44-168,333-460]
Synonyms:
BET bromodomain 4(1,2) (BRD4(1,2)) | BRD4 | BRD4_HUMAN | HUNK1
Type:
n/a
Mol. Mass.:
29666.85
Organism:
Homo sapiens (Human)
Description:
O60885 (BRD4, 44-168 and 333-460)
Residue:
253
Sequence:
NPPPPETSNPNKPKRQTNQLQYLLRVVLKTLWKHQFAWPFQQPVDAVKLNLPDYYKIIKTPMDMGTIKKRLENNYYWNAQECIQDFNTMFTNCYIYNKPGDDIVLMAEALEKLFLQKINELPTEEKDVPDSQQHPAPEKSSKVSEQLKCCSGILKEMFAKKHAAYAWPFYKPVDVEALGLHDYCDIIKHPMDMSTIKSKLEAREYRDAQEFGADVRLMFSNCYKYNPPDHEVVAMARKLQDVFEMRFAKMPDE
  
Inhibitor
Name:
BDBM205453
Synonyms:
MTI (35)
Type:
Small organic molecule
Emp. Form.:
C54H66Cl2N10O9S2
Mol. Mass.:
1134.199
SMILES:
Cc1sc-2c(c1C)C(=NC(CC(=O)NCCOCCOCCOCCOCCOCCOCCOCCNC(=O)C[C@@H]1N=C(c3c(C)c(C)sc3-n3c(C)nnc13)c1ccc(Cl)cc1)c1nnc(C)n-21)c1ccc(Cl)cc1 |r,c:8,43|
Structure:
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