Target
Interleukin-1 receptor-associated kinase 4
Ligand
BDBM206101
Substrate
IRAK-4 Peptide Substrate
Meas. Tech.
In vitro IRAK-1 and IRAK-4 Assay
IC50
12±n/a nM
Citation
 Arora, NChen, SHermann, JCKuglstatter, ALabadie, SSLin, CJLucas, MCMoore, AGPapp, ETalamas, FXWanner, JZhai, Y Pyrazolo[1,5a]pyrimidine derivatives as IRAK4 modulators US Patent  US9255110 Publication Date 2/9/2016 
Target
Name:
Interleukin-1 receptor-associated kinase 4
Synonyms:
IRAK-4 | IRAK4 | IRAK4_HUMAN | Interleukin-1 receptor-associated kinase 4 (IRAK-4) | Interleukin-1 receptor-associated kinase 4 (IRAK4) | Renal carcinoma antigen NY-REN-64
Type:
Protein
Mol. Mass.:
51519.08
Organism:
Homo sapiens (Human)
Description:
Q9NWZ3
Residue:
460
Sequence:
MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS
  
Inhibitor
Name:
BDBM206101
Synonyms:
US9255110, 14
Type:
Small organic molecule
Emp. Form.:
C22H22N6OS
Mol. Mass.:
418.515
SMILES:
NCC1CCN(CC1)c1cc2ncccc2cc1NC(=O)c1csc2cncnc12
Structure:
Search PDB for entries with ligand similarity:
Substrate
Name:
IRAK-4 Peptide Substrate
Synonyms:
n/a
Type:
Enzyme
Mol. Mass.:
2290.62
Organism:
Homo sapiens (Human)
Description:
IRAK-1 (360-380); IRAK-4 Peptide Substrate
Residue:
21
Sequence:
KKARFSRFAGSSPSQSSMVAR