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Target
Aurora kinase A
Ligand
BDBM92824
Substrate
n/a
Meas. Tech.
Isothermal titration calorimetry (ITC)
pH
7.4±n/a
IC50
149±23 nM
Kd
299±27 nM
Comments
extracted
Citation
 Sebti, SM; Schönbrunn, E; Lawrence, NJ; Lawrence, HR; Martin, MP Aurora kinase inhibitors and methods of making and using thereof US Patent  US9249124 Publication Date 2/2/2016 
Target
Name:
Aurora kinase A
Synonyms:
AIK | AIRK1 | ARK1 | AURA | AURKA | AURKA_HUMAN | AYK1 | Aurora 2 | Aurora kinase A (AURA) | Aurora kinase A (AURKA) | Aurora kinase A (Aurora A) | Aurora kinase A (Aurora-2) | Aurora-related kinase 1 | Aurora/IPL1-related kinase 1 | BTAK | Breast tumor-amplified kinase | Breast-tumor-amplified kinase | IAK1 | STK15 | STK6 | Serine/threonine kinase 15 | Serine/threonine-protein kinase 6 | Serine/threonine-protein kinase aurora A | aurora-2 | hARK1
Type:
Serine/threonine-protein kinase
Mol. Mass.:
45830.98
Organism:
Homo sapiens (Human)
Description:
O14965
Residue:
403
Sequence:
MDRSKENCISGPVKATAPVGGPKRVLVTQQFPCQNPLPVNSGQAQRVLCPSNSSQRVPLQAQKLVSSHKPVQNQKQKQLQATSVPHPVSRPLNNTQKSKQPLPSAPENNPEEELASKQKNEESKKRQWALEDFEIGRPLGKGKFGNVYLAREKQSKFILALKVLFKAQLEKAGVEHQLRREVEIQSHLRHPNILRLYGYFHDATRVYLILEYAPLGTVYRELQKLSKFDEQRTATYITELANALSYCHSKRVIHRDIKPENLLLGSAGELKIADFGWSVHAPSSRRTTLCGTLDYLPPEMIEGRMHDEKVDLWSLGVLCYEFLVGKPPFEANTYQETYKRISRVEFTFPDFVTEGARDLISRLLKHNPSQRPMLREVLEHPWITANSSKPSNCQNKESASKQS
  
Inhibitor
Name:
BDBM92824
Synonyms:
Bisanilinopyrimidine, 6q | US9249124, 40
Type:
Small molecule
Emp. Form.:
C23H18N4O2
Mol. Mass.:
382.4146
SMILES:
OC(=O)c1ccc(Nc2nccc(Nc3ccccc3-c3ccccc3)n2)cc1
Structure:
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