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Target
Acetyl-CoA carboxylase 2 [129-967]
Ligand
BDBM212717
Substrate
n/a
Meas. Tech.
Spectrophotometric 384 Well Assay
pH
7.5±n/a
IC50
280±n/a nM
Comments
extracted
Citation
 Heine, N; Fleck, M; Nosse, B; Roth, GJ Pyrrolidine derivatives, pharmaceutical compositions and uses thereof US Patent  US9278954 Publication Date 3/8/2016 
Target
Name:
Acetyl-CoA carboxylase 2 [129-967]
Synonyms:
ACACB | ACACB_HUMAN | ACC2 | ACCB | Acetyl-CoA carboxylase 2 (ACC2)
Type:
Enzyme
Mol. Mass.:
92599.28
Organism:
Homo sapiens (Human)
Description:
O00763 lacks the 128 amino acids at the N-terminus
Residue:
839
Sequence:
DTNGLSSSARPQGQQAGSPSKEDKKQANIKRQLMTNFILGSFDDYSSDEDSVAGSSRESTRKGSRASLGALSLEAYLTTGEAETRVPTMRPSMSGLHLVKRGREHKKLDLHRDFTVASPAEFVTRFGGDRVIEKVLIANNGIAAVKCMRSIRRWAYEMFRNERAIRFVVMVTPEDLKANAEYIKMADHYVPVPGGPNNNNYANVELIVDIAKRIPVQAVWAGWGHASENPKLPELLCKNGVAFLGPPSEAMWALGDKIASTVVAQTLQVPTLPWSGSGLTVEWTEDDLQQGKRISVPEDVYDKGCVKDVDEGLEAAERIGFPLMIKASEGGGGKGIRKAESAEDFPILFRQVQSEIPGSPIFLMKLAQHARHLEVQILADQYGNAVSLFGRDCSIQRRHQKIVEEAPATIAPLAIFEFMEQCAIRLAKTVGYVSAGTVEYLYSQDGSFHFLELNPRLQVEHPCTEMIADVNLPAAQLQIAMGVPLHRLKDIRLLYGESPWGVTPISFETPSNPPLARGHVIAARITSENPDEGFKPSSGTVQELNFRSSKNVWGYFSVAATGGLHEFADSQFGHCFSWGENREEAISNMVVALKELSIRGDFRTTVEYLINLLETESFQNNDIDTGWLDYLIAEKVQAEKPDIMLGVVCGALNVADAMFRTCMTDFLHSLERGQVLPADSLLNLVDVELIYGGVKYILKVARQSLTMFVLIMNGCHIEIDAHRLNDGGLLLSYNGNSYTTYMKEEVDSYRITIGNKTCVFEKENDPTVLRSPSAGKLTQYTVEDGGHVEAGSSYAEMEVMKMIMTLNVQERGRVKYIKRPGAVLEAGCVVARLELDDPS
  
Inhibitor
Name:
BDBM212717
Synonyms:
US9278954, 3.3
Type:
Small organic molecule
Emp. Form.:
C23H30FN5O2
Mol. Mass.:
427.515
SMILES:
CCCNc1ncnc(N2CC[C@H](C2)Oc2ccc(cc2)C(C)C(=O)NC2CC2)c1F |r|
Structure:
Search PDB for entries with ligand similarity: