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TargetTyrosine-protein kinase ABL1
LigandBDBM213623
Substrate/Competitorn/a
Meas. Tech.Radio ABL1 (64-515) Assay
pH7.5±n/a
Temperature298.15±n/a K
IC50 1.2±n/a nM
Commentsextracted
Citation Furet, PGrotzfeld, RMJahnke, WJones, DBManley, PWMarzinzik, APelle, XFSalem, BSchoepfer, JSpieser, EA Compounds and compositions for inhibiting the activity of ABL1, ABL2 and BCR-ABL1 US Patent US9278981 Publication Date 3/8/2016
More Info.:Get all data from this article,  Assay Method
 
Tyrosine-protein kinase ABL1
Name:Tyrosine-protein kinase ABL1
Synonyms:Tyrosine-protein kinase ABL1 (64-515) | Tyrosine-protein kinase ABL1 (ABL) | Tyrosine-protein kinase ABL1 (ABL1)
Type:Enzyme Catalytic Domain
Mol. Mass.:51539.77
Organism:Homo sapiens (Human)
Description:aa 64-515
Residue:452
Sequence:
NLFVALYDFVASGDNTLSITKGEKLRVLGYNHNGEWCEAQTKNGQGWVPSNYITPVNSLE
KHSWYHGPVSRNAAEYLLSSGINGSFLVRESESSPGQRSISLRYEGRVYHYRINTASDGK
LYVSSESRFNTLAELVHHHSTVADGLITTLHYPAPKRNKPTVYGVSPNYDKWEMERTDIT
MKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQLLG
VCTREPPFYIITEFMTYGNLLDYLRECNRQEVNAVVLLYMATQISSAMEYLEKKNFIHRD
LAARNCLVGENHLVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNKFSIKSDVW
AFGVLLWEIATYGMSPYPGIDLSQVYELLEKDYRMERPEGCPEKVYELMRACWQWNPSDR
PSFAEIHQAFETMFQESSISDEVEKELGKQGV
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM213623
NameBDBM213623
Synonyms:US9278981, 215
TypeSmall organic molecule
Emp. Form.C22H21F2N5O3
Mol. Mass.441.4306
SMILESCC(F)(F)Oc1ccc(NC(=O)c2cnc(N3CC[C@@H](O)C3)c(c2)-c2cncnc2)cc1 |r|
Structure
n/a