Reaction Details Report a problem with these data
Target
Muscarinic acetylcholine receptor M3 [1-273,470-589,N6Q,N15Q,N41Q,N48Q,N52Q,T556C]
Ligand
BDBM50004656
Substrate
n/a
Meas. Tech.
[3H]NMS/Carbachol Binding Assay
pH
7.4±n/a
Ki
1.82e+4± 3.8e+3 nM
Comments
extracted
Citation
Hu, J; Hu, K; Liu, T; Stern, MK; Mistry, R; Challiss, RA; Costanzi, S; Wess, J Novel structural and functional insights into M3 muscarinic receptor dimer/oligomer formation. J Biol Chem 288:34777-90 (2013) [PubMed] Article
More Info.:
Target
Name:
Muscarinic acetylcholine receptor M3 [1-273,470-589,N6Q,N15Q,N41Q,N48Q,N52Q,T556C]
Synonyms:
ACM3_RAT | Chrm-3 | Chrm3 | M3 muscarinic receptor (M3'(3C)-Xa T556C)
Type:
Protein
Mol. Mass.:
46048.67
Organism:
Rattus norvegicus (Rat)
Description:
Rat M3'(3C)-Xa with T556C mutation
Residue:
405
Sequence:
MTLHSQSTTSPLFPQISSSWVHSPSEAGLPLGTVTQLGSYQISQETGQFSSQDTSSDPLGGHTIWQVVFIAFLTGFLALVTIIGNILVIVAFKVNKQLKTVNNYFLLSLACADLIIGVISMNLFTTYIIMNRWALGNLACDLWLSIDYVASNASVMNLLVISFDRYFSITRPLTYRAKRTTKRAGVMIGLAWVISFVLWAPAILFWQYFVGKRTVPPGECFIQFLSEPTITFGTAIAAFYMPVTIMTILYWRIYKETEKRTKELAGLQASGTEIEGRIEGRIEGRTRSQITKRKRMSLIKEKKAAQTLSAILLAFIITWTPYNIMVLVNTFCDSCIPKTYWNLGYWLCYINSTVNPVCYALCNKTFRTTFKCLLLCQCDKRKRRKQQYQQRQSVIFHKRVPEQAL
Inhibitor
Name:
BDBM50004656
Synonyms:
(2-Carbamoyloxy-ethyl)-trimethyl-ammonium | (2-Carbamoyloxyethyl)trimethylammonium chloride | (2-Hydroxyethyl)trimethyl ammonium chloride carbamate | (2-Hydroxyethyl)trimethylammonium chloride carbamate | (carbachol)(2-Carbamoyloxy-ethyl)-trimethyl-ammonium | 2-((Aminocarbonyl)oxy)-N,N,N-trimethylethanaminium chloride | 2-((Aminocarbonyl)oxy)-N,N,N-trimethylethanaminum chloride | 2-(carbamoyloxy)-N,N,N-trimethylethanaminium | 2-(carbamoyloxy)-N,N,N-trimethylethanaminium chloride | CARBACHOL | CARBASTAT | CHEMBL14 | Carbachol chloride | Carbamylcholine | Choline carbamate chloride | Choline chloride, carbamate | Choline chlorine carbamate | Karbachol | Karbamoylcholin chlorid | MIOSTAT
Type:
Small organic molecule
Emp. Form.:
C6H15N2O2
Mol. Mass.:
147.195
SMILES:
C[N+](C)(C)CCOC(N)=O