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TargetGST-MKNK1
LigandBDBM218768
Substrate/Competitorn/a
Meas. Tech.MKNK1 Kinase High ATP Assay
pH7.5±n/a
Temperature295.15±n/a K
IC50 1±n/a nM
Commentsextracted
Citation Klar, UKettschau, GKosemund, DPühler, FEis, KLienau, PBömer, USülzle, DWortmann, L Substituted benzothienopyrimidines US Patent US9296757 Publication Date 3/29/2016
More Info.:Get all data from this article,  Assay Method
 
GST-MKNK1
Name:GST-MKNK1
Synonyms:n/a
Type:Enzyme
Mol. Mass.:n/a
Description:n/a
Components:This complex has 2 components.
Component 1
Name:Glutathione S-transferase (GST)
Synonyms:GST class-alpha member 1 | GST-epsilon | GSTA1-1 | GTH1 | Glutathione S-transferase A1 | Glutathione S-transferase A1 | HA subunit 1
Type:Enzyme
Mol. Mass.:25636.31
Organism:Homo sapiens (Human)
Description:Glutathione-S-Transferase (GST, N-terminally)
Residue:222
Sequence:
MAEKPKLHYFNARGRMESTRWLLAAAGVEFEEKFIKSAEDLDKLRNDGYLMFQQVPMVEI
DGMKLVQTRAILNYIASKYNLYGKDIKERALIDMYIEGIADLGEMILLLPVCPPEEKDAK
LALIKEKIKNRYFPAFEKVLKSHGQDYLVGNKLSRADIHLVELLYYVEELDSSLISSFPL
LKALKTRISNLPTVKKFLQPGSPRKPPMDEKSLEEARKIFRF
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Component 2
Name:MAP kinase-interacting serine/threonine-protein kinase 1 (T344D)
Synonyms:MAP kinase signal-integrating kinase 1 (MNK1) (T344D) | MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1) (T344D) | MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1)(T344D) | MKNK1 (aa 1-424) T344D | MNK1a
Type:Protein
Mol. Mass.:47416.00
Organism:Homo sapiens (Human)
Description:Q9BUB5-2 with T344D
Residue:424
Sequence:
MVSSQKLEKPIEMGSSEPLPIADGDRRRKKKRRGRATDSLPGKFEDMYKLTSELLGEGAY
AKVQGAVSLQNGKEYAVKIIEKQAGHSRSRVFREVETLYQCQGNKNILELIEFFEDDTRF
YLVFEKLQGGSILAHIQKQKHFNEREASRVVRDVAAALDFLHTKGIAHRDLKPENILCES
PEKVSPVKICDFDLGSGMKLNNSCTPITTPELTTPCGSAEYMAPEVVEVFTDQATFYDKR
CDLWSLGVVLYIMLSGYPPFVGHCGADCGWDRGEVCRVCQNKLFESIQEGKYEFPDKDWA
HISSEAKDLISKLLVRDAKQRLSAAQVLQHPWVQGQAPEKGLPDPQVLQRNSSTMDLTLF
AAEAIALNRQLSQHEENELAEEPEALADGLCSMKLSPPCKSRLARRRALAQAGRGEDRSP
PTAL
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BDBM218768
NameBDBM218768
Synonyms:US9296757, 90
TypeSmall organic molecule
Emp. Form.C24H27N5O4S2
Mol. Mass.513.632
SMILESCCN(CCOC)C(=O)C1CCc2c(C1)sc1ncnc(Nc3cc4sc(=O)[nH]c4cc3OC)c21 |w:9.8|
Structure
n/a