Target
Diacylglycerol O-acyltransferase 1
Ligand
BDBM220981
Substrate
n/a
Meas. Tech.
DGAT1 Inhibitory Assay
pH
7.4±n/a
Temperature
303.15±n/a K
IC50
3.1±n/a nM
Comments
extracted
Citation
 Sakurai, OSaruta, KHayashi, NGoi, TMorokuma, KTsujishima, HSawamoto, HShitama, HImashiro, R Continuous arycyclic compound US Patent  US9302996 Publication Date 4/5/2016 
Target
Name:
Diacylglycerol O-acyltransferase 1
Synonyms:
ACAT-related gene product 1 | AGRP1 | Acyl coA-diacylglycerol acyl transferase 1 (DGAT1) | DGAT | DGAT1 | DGAT1_HUMAN | Diacylglycerol Acyltransferase (DGAT1) | Diacylglycerol O-acyltransferase 1 | Diacylglycerol O-acyltransferase 1 (DGAT1) | Diglyceride acyltransferase
Type:
Protein
Mol. Mass.:
55297.82
Organism:
Homo sapiens (Human)
Description:
O75907
Residue:
488
Sequence:
MGDRGSSRRRRTGSRPSSHGGGGPAAAEEEVRDAAAGPDVGAAGDAPAPAPNKDGDAGVGSGHWELRCHRLQDSLFSSDSGFSNYRGILNWCVVMLILSNARLFLENLIKYGILVDPIQVVSLFLKDPYSWPAPCLVIAANVFAVAAFQVEKRLAVGALTEQAGLLLHVANLATILCFPAAVVLLVESITPVGSLLALMAHTILFLKLFSYRDVNSWCRRARAKAASAGKKASSAAAPHTVSYPDNLTYRDLYYFLFAPTLCYELNFPRSPRIRKRFLLRRILEMLFFTQLQVGLIQQWMVPTIQNSMKPFKDMDYSRIIERLLKLAVPNHLIWLIFFYWLFHSCLNAVAELMQFGDREFYRDWWNSESVTYFWQNWNIPVHKWCIRHFYKPMLRRGSSKWMARTGVFLASAFFHEYLVSVPLRMFRLWAFTGMMAQIPLAWFVGRFFQGNYGNAAVWLSLIIGQPIAVLMYVHDYYVLNYEAPAAEA
  
Inhibitor
Name:
BDBM220981
Synonyms:
US9302996, 96-2
Type:
Small organic molecule
Emp. Form.:
C24H26FN3O3
Mol. Mass.:
423.4799
SMILES:
Cc1cc(OCC(C)(C)C(O)=O)ncc1-c1ccc(-c2ncc(CC3CC3)[nH]2)c(F)c1
Structure:
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