Reaction Details Report a problem with these data
Target
SRSF protein kinase 1
Ligand
BDBM221074
Substrate
n/a
Meas. Tech.
In Vitro Kinase Screening Assay
pH
7.5±n/a
Temperature
303.15±n/a K
IC50
5.9±0.0 nM
Comments
extracted
Citation
 Batson, J; Toop, HD; Redondo, C; Babaei-Jadidi, R; Chaikuad, A; Wearmouth, SF; Gibbons, B; Allen, C; Tallant, C; Zhang, J; Du, C; Hancox, JC; Hawtrey, T; Da Rocha, J; Griffith, R; Knapp, S; Bates, DO; Morris, JC Development of Potent, Selective SRPK1 Inhibitors as Potential Topical Therapeutics for Neovascular Eye Disease. ACS Chem Biol 12:825-832 (2017) [PubMed]  Article 
Target
Name:
SRSF protein kinase 1
Synonyms:
SRPK1 | SRPK1_HUMAN | SRSF protein kinase 1 (SRPK1) | Serine/arginine-protein kinase 1 (SRPK1) | Serine/threonine-protein kinase SRPK1
Type:
Protein
Mol. Mass.:
74318.38
Organism:
Homo sapiens (Human)
Description:
Q96SB4
Residue:
655
Sequence:
MERKVLALQARKKRTKAKKDKAQRKSETQHRGSAPHSESDLPEQEEEILGSDDDEQEDPNDYCKGGYHLVKIGDLFNGRYHVIRKLGWGHFSTVWLSWDIQGKKFVAMKVVKSAEHYTETALDEIRLLKSVRNSDPNDPNREMVVQLLDDFKISGVNGTHICMVFEVLGHHLLKWIIKSNYQGLPLPCVKKIIQQVLQGLDYLHTKCRIIHTDIKPENILLSVNEQYIRRLAAEATEWQRSGAPPPSGSAVSTAPQPKPADKMSKNKKKKLKKKQKRQAELLEKRMQEIEEMEKESGPGQKRPNKQEESESPVERPLKENPPNKMTQEKLEESSTIGQDQTLMERDTEGGAAEINCNGVIEVINYTQNSNNETLRHKEDLHNANDCDVQNLNQESSFLSSQNGDSSTSQETDSCTPITSEVSDTMVCQSSSTVGQSFSEQHISQLQESIRAEIPCEDEQEQEHNGPLDNKGKSTAGNFLVNPLEPKNAEKLKVKIADLGNACWVHKHFTEDIQTRQYRSLEVLIGSGYNTPADIWSTACMAFELATGDYLFEPHSGEEYTRDEDHIALIIELLGKVPRKLIVAGKYSKEFFTKKGDLKHITKLKPWGLFEVLVEKYEWSQEEAAGFTDFLLPMLELIPEKRATAAECLRHPWLNS
  
Inhibitor
Name:
BDBM221074
Synonyms:
SPHINX31 | US9695160, 12 | US9796707, Compound 12
Type:
Small organic molecule
Emp. Form.:
C27H24F3N5O2
Mol. Mass.:
507.507
SMILES:
FC(F)(F)c1ccc(N2CCN(Cc3ccccn3)CC2)c(NC(=O)c2ccc(o2)-c2ccncc2)c1
Structure:
Search PDB for entries with ligand similarity: